DNA damage and ageing: new-age ideas for an age-old problem

被引：254

作者：

Garinis, George A. ^{[1
]}

van der Horst, Gijsbertus T. J. ^{[1
]}

Vijg, Jan ^{[2
]}

Hoeijmakers, Jan H. J. ^{[1
]}

机构：

[1] Erasmus Univ, Med Ctr, Dept Genet, Ctr Biomed Genet, NL-3000 CA Rotterdam, Netherlands

[2] Buck Inst Aging Res, Novato, CA 94945 USA

来源：

NATURE CELL BIOLOGY | 2008年 / 10卷 / 11期

关键词：

D O I：

10.1038/ncb1108-1241

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Loss of genome maintenance may causally contribute to ageing, as exemplified by the premature appearance of multiple symptoms of ageing in a growing family of human syndromes and in mice with genetic defects in genome maintenance pathways. Recent evidence revealed a similarity between such prematurely ageing mutants and long-lived mice harbouring mutations in growth signalling pathways. At first sight this seems paradoxical as they represent both extremes of ageing yet show a similar 'survival' response that is capable of delaying age-related pathology and extending lifespan. Understanding the mechanistic basis of this response and its connection with genome maintenance would open exciting possibilities for counteracting cancer or age-related diseases, and for promoting longevity.

引用

页码：1241 / 1247

页数：7

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