Measures of acidosis with repetitive umbilical cord occlusions leading to fetal asphyxia in the near-term ovine fetus

被引：42

作者：

Frasch, Martin G. ^{[1
]}

Mansano, Roy Z. ^{[2
]}

Gagnon, Robert ^{[1
]}

Richardson, Bryan S. ^{[1
]}

Ross, Michael G. ^{[2
]}

机构：

[1] Univ Western Ontario, Dept Obstet & Gynaecol, Lawson Hlth Res Inst, London, ON, Canada

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90095 USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2009年 / 200卷 / 02期

关键词：

base deficit; blood gases; fetal asphyxia; lactate; RED-BLOOD-CELLS; METABOLIC-RESPONSES; INFANTS; MARKER; DECELERATIONS; SUFFICIENT; INJURY; LABOR; BIRTH; PH;

D O I：

10.1016/j.ajog.2008.10.022

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: Increasing frequency of severe variable decelerations is associated with acidemia. However, there is little understanding of its development or normalization rate. STUDY DESIGN: To quantify the time course of acidemia, 10 near-term fetal sheep underwent a series of mild (1 minute every 5 minutes), moderate (1 minute every 3 minutes), and severe (1 minute every 2 minutes) umbilical cord occlusions (UCO), lasting 1 hour each or until fetal arterial pH decreased to less than 7.00. RESULTS: Each minute of UCO resulted in base deficit (BD) and lactate increases at rates of 0.56 and 0.35 mmol/L per minute, respectively. During a 2 h recovery, BD and lactate normalized at rates of 0.09 and 0.04 mmol/L per minute. BD correlated highly with lactate (r = 0.95; P < .001). CONCLUSION: Our findings in the near-term ovine fetus suggest that the knowledge of fetal BD deterioration and recovery rates can aid assessing fetal acidemia during labor.

引用

页码：200.e1 / 200.e7

页数：7