MicroRNAs target the Wnt/β-catenin signaling pathway to regulate epithelial-mesenchymal transition in cancer

被引：54
|
作者：
Lei, Yuhe [1 ]
Chen, Lei [1 ]
Zhang, Ge [2 ]
Shan, Aiyun [1 ]
Ye, Chunfeng [3 ]
Liang, Bin [4 ]
Sun, Jiayu [1 ]
Liao, Xin [1 ]
Zhu, Changfeng [1 ]
Chen, Yueyue [4 ]
Wang, Jing [4 ]
Zhang, Enxin [5 ]
Deng, Lijuan [4 ]
机构：
[1] Guangzhou Univ Chinese Med, Shenzhen Hosp, Dept Pharm, Shenzhen 518000, Guangdong, Peoples R China
[2] Guangdong Prov Hosp Chinese Med, Dept Big Data Res Chinese Med, Guangzhou 510120, Guangdong, Peoples R China
[3] Nanchang Univ, Affiliated Hosp 2, Dept Pediat, Nanchang 330006, Jiangxi, Peoples R China
[4] Jinan Univ, Formula Pattern Res Ctr, Sch Tradit Chinese Med, 605 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China
[5] Guangzhou Univ Chinese Med, Shenzhen Hosp, Dept Oncol, 6001 Beihuan Ave, Shenzhen 518000, Guangdong, Peoples R China
来源：
ONCOLOGY REPORTS | 2020年 / 44卷 / 04期
基金：
中国国家自然科学基金;
关键词：
microRNA; Wnt/beta-catenin signaling; epithelial-mesenchymal transition; cancer metastasis; cancer therapy; CELL LUNG-CANCER; BETA-CATENIN; E-CADHERIN; HEPATOCELLULAR-CARCINOMA; PANCREATIC-CANCER; COLORECTAL-CANCER; DOWN-REGULATION; INHIBITS PROLIFERATION; POSTTRANSCRIPTIONAL REGULATION; NUCLEAR TRANSLOCATION;
D O I：
10.3892/or.2020.7703
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Epithelial-mesenchymal transition (EMT), during which cancer cells lose the epithelial phenotype and gain the mesenchymal phenotype, has been verified to result in tumor migration and invasion. Numerous studies have shown that dysregulation of the Wnt/beta-catenin signaling pathway gives rise to EMT, which is characterized by nuclear translocation of beta-catenin and E-cadherin suppression. Wnt/beta-catenin signaling was confirmed to be affected by microRNAs (miRNAs), several of which are down- or upregulated in metastatic cancer cells, indicating their complex roles in Wnt/beta-catenin signaling. In this review, we demonstrated the targets of various miRNAs in altering Wnt/beta-catenin signaling to promote or inhibit EMT, which may elucidate the underlying mechanism of EMT regulation by miRNAs and provide evidence for potential therapeutic targets in the treatment of invasive tumors.
引用
收藏
页码：1299 / 1313
页数：15
相关论文
共 50 条
  • [31] MIR-519d suppresses the gastric cancer epithelial-mesenchymal transition via Twist1 and inhibits Wnt/β-catenin signaling pathway
    Yue, Hailing
    Tang, Bo
    Zhao, Yongliang
    Niu, Yanyang
    Yin, Peng
    Yang, Weijun
    Zhang, Zhigang
    Yu, Peiwu
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2017, 9 (08): : 3654 - 3664
  • [32] Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/β-catenin pathway
    Wang, Enwen
    Wang, Donglin
    Li, Bing
    Ma, Huiwen
    Wang, Chunmei
    Guan, Lili
    Zhang, Haiwei
    Yi, Lin
    Li, Shaolin
    ONCOLOGY REPORTS, 2017, 37 (01) : 379 - 387
  • [33] MicroRNAs in Epithelial-Mesenchymal Transition Process of Cancer: Potential Targets for Chemotherapy
    Peng, Fu
    Fan, Huali
    Li, Sui
    Peng, Cheng
    Pan, Xiaoqi
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (14)
  • [34] 2′-Hydroxyflavanone inhibits epithelial-mesenchymal transition, and cell migration and invasion via suppression of the Wnt/β-catenin signaling pathway in prostate cancer
    Wu, Shiqi
    Huang, Jun
    Hui, Ke
    Yue, Yangyang
    Gu, Yanan
    Ning, Zhongyun
    Wang, Xinyang
    He, Dalin
    Wu, Kaijie
    ONCOLOGY REPORTS, 2018, 40 (05) : 2836 - 2843
  • [35] Involvement of Wnt/β-catenin pathway in the inhibition of invasion and epithelial-mesenchymal transition in ovarian cancer cells
    Ekem, Belikiz
    Gong, Wei
    Han, Lu
    Wang, Xinmei
    Liu, Na
    Wan, Li
    Guo, Qin
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2020, 19 (07) : 1365 - 1370
  • [36] Knockdown of IQGAPI inhibits proliferation and epithelial-mesenchymal transition by Wnt/β-catenin pathway in thyroid cancer
    Su, Dongyue
    Liu, Yang
    Song, Tao
    ONCOTARGETS AND THERAPY, 2017, 10 : 1549 - 1559
  • [37] Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway
    YaJie Li
    Yan Zhao
    Yi Li
    XiaoYi Zhang
    Chao Li
    NiYa Long
    XueShu Chen
    LiYa Bao
    JianJiang Zhou
    Yuan Xie
    Journal of Physiology and Biochemistry, 2021, 77 : 93 - 104
  • [38] Overexpression of NCAPG inhibits cardia adenocarcinoma apoptosis and promotes epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway
    Zhang, Xinxin
    Zhu, Mengqi
    Wang, Hui
    Song, Zaozhi
    Zhan, Danka
    Cao, Wenjing
    Han, Yajuan
    Jia, Jianguang
    GENE, 2021, 766
  • [39] Wnt/β-catenin signalling, epithelial-mesenchymal transition and crosslink signalling in colorectal cancer cells
    Sun, Luanbiao
    Xing, Jianpeng
    Zhou, Xuanpeng
    Song, Xinyuan
    Gao, Shuohui
    BIOMEDICINE & PHARMACOTHERAPY, 2024, 175
  • [40] IGFBP2 drives epithelial-mesenchymal transition in hepatocellular carcinoma via activating the Wnt/β-catenin pathway
    Chen, Xiu
    Zhang, Yu
    Zhang, Pingping
    Wei, Mengzhu
    Tian, Tian
    Guan, Yanling
    Han, Chenchen
    Wei, Wei
    Ma, Yang
    INFECTIOUS AGENTS AND CANCER, 2023, 18 (01)
12345