γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia

被引：22

作者：

Luong-Gardiol, Noemie ^{[1
,8
]}

Siddiqui, Imran ^{[1
]}

Pizzitola, Irene ^{[1
]}

Jeevan-Raj, Beena ^{[1
]}

Charmoy, Melanie ^{[1
]}

Huang, Yun ^{[2
,3
]}

Irmisch, Anja ^{[4
,9
]}

Curtet, Sara ^{[1
]}

Angelov, Georgi S. ^{[1
]}

Danilo, Maxime ^{[1
,10
]}

Juilland, Melanie ^{[5
]}

Bornhauser, Beat ^{[2
,3
]}

Thome, Margot ^{[5
]}

Hantschel, Oliver ^{[4
]}

Chalandon, Yves ^{[6
]}

Cazzaniga, Gianni ^{[7
]}

Bourquin, Jean-Pierre ^{[2
,3
]}

Huelsken, Joerg ^{[4
]}

Held, Werner ^{[1
]}

机构：

[1] Univ Lausanne, Dept Oncol UNIL CHUV, Epalinges, Switzerland

[2] Univ Childrens Hosp Zurich, Dept Pediat Oncol, Zurich, Switzerland

[3] Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland

[4] Fed Univ Technol Lausanne EPFL, Swiss Inst Expt Canc Res ISREC, Lausanne, Switzerland

[5] Univ Lausanne, Dept Biochem, Epalinges, Switzerland

[6] Hop Univ Geneve, Serv Hematol, Geneva, Switzerland

[7] Pediat Clin Univ Milano Bicocca, Ctr Ric Tettamanti, Monza, Italy

[8] Debiopharm Int SA, Ch Messidor 5-7, CH-1002 Lausanne, Switzerland

[9] Univ Hosp Zurich, Clin Dermatol, Wagistr 14, CH-8952 Schlieren, Switzerland

[10] Phi Pharma SA, Pl Midi 36, CH-1950 Sion, Switzerland

来源：

CANCER CELL | 2019年 / 35卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

CHRONIC MYELOID-LEUKEMIA; BETA-CATENIN; STEM-CELLS; C-MYC; BCR-ABL; TRANSCRIPTIONAL REGULATION; TRANSLOCATION PRODUCTS; SURVIVIN; PATHWAY; KINASE;

D O I：

10.1016/j.ccell.2019.03.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The BCR-ABL1 fusion protein is the cause of chronic myeloid leukemia (CML) and of a significant fraction of adult-onset B cell acute lymphoblastic leukemia (B-ALL) cases. Using mouse models and patient-derived samples, we identified an essential role for gamma-catenin in the initiation and maintenance of BCR-ABL1(+) B-ALL but not CML. The selectivity was explained by a partial gamma-catenin dependence of MYC expression together with the susceptibility of B-ALL, but not CML, to reduced MYC levels. MYC and gamma-catenin enabled B-ALL maintenance by augmenting BIRC5 and enforced BIRC5 expression overcame gamma-catenin loss. Since gamma-catenin was dispensable for normal hematopoiesis, these lineage- and disease-specific features of canonical Wnt signaling identified a potential therapeutic target for the treatment of BCR-ABL1(+) B-ALL.

引用

页码：649 / +

页数：25

共 52 条

[21] The Gamma Catenin/CBP Complex Maintains Survivin Transcription in β-catenin Deficient/Depleted Cancer Cells [J].

Kim, Y. -M. ;

Ma, H. ;

Oehler, V. G. ;

Gang, E. J. ;

Nguyen, C. ;

Masiello, D. ;

Liu, H. ;

Zhao, Y. ;

Radich, J. ;

Kahn, M. .

CURRENT CANCER DRUG TARGETS, 2011, 11 (02) :213-225

[22] Keratinocyte transcriptional regulation of the human c-Myc promoter occurs via a novel Lef/Tcf binding element distinct from neoplastic cells [J].

Kolly, Carine ;

Zakher, Antony ;

Strauss, Christian ;

Suter, Maja M. ;

Mueller, Eliane J. .

FEBS LETTERS, 2007, 581 (10) :1969-1976

[23] Diverging fates of cells of origin in acute and chronic leukaemia [J].

Kovacic, Boris ;

Hoelbl, Andrea ;

Litos, Gabriele ;

Alacakaptan, Memetcan ;

Schuster, Christian ;

Fischhuber, Katrin M. ;

Kerenyi, Marc A. ;

Stengl, Gabriele ;

Moriggl, Richard ;

Sexl, Veronika ;

Beug, Hartmut .

EMBO MOLECULAR MEDICINE, 2012, 4 (04) :283-297

[24] Cardiac Tissue-Restricted Deletion of Plakoglobin Results in Progressive Cardiomyopathy and Activation of β-Catenin Signaling [J].

Li, Jifen ;

Swope, David ;

Raess, Natalia ;

Cheng, Lan ;

Muller, Eliane J. ;

Radice, Glenn L. .

MOLECULAR AND CELLULAR BIOLOGY, 2011, 31 (06) :1134-1144

[25] Activation of the Wnt signaling pathway in chronic lymphocytic leukemia [J].

Lu, DS ;

Zhao, YD ;

Tawatao, R ;

Cottam, HB ;

Sen, M ;

Leoni, LM ;

Kipps, TJ ;

Corr, M ;

Carson, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :3118-3123

[26] Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates β-catenin-mediated transcription [J].

Miravet, S ;

Piedra, J ;

Castaño, J ;

Raurell, I ;

Francí, C ;

Duñach, M ;

de Herreros, AG .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (20) :7391-7402

[27] γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin [J].

Morgan, R. G. ;

Pearn, L. ;

Liddiard, K. ;

Pumford, S. L. ;

Burnett, A. K. ;

Tonks, A. ;

Darley, R. L. .

LEUKEMIA, 2013, 27 (02) :336-343

[28] Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells [J].

Müller-Tidow, C ;

Steffen, B ;

Cauvet, T ;

Tickenbrock, L ;

Ji, P ;

Diederichs, S ;

Sargin, B ;

Köhler, G ;

Stelljes, M ;

Puccetti, E ;

Ruthardt, M ;

deVos, S ;

Hiebert, SW ;

Koeffler, HP ;

Berdel, WE ;

Serve, H .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (07) :2890-2904

[29] BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros [J].

Mullighan, Charles G. ;

Miller, Christopher B. ;

Radtke, Ina ;

Phillips, Letha A. ;

Dalton, James ;

Ma, Jing ;

White, Deborah ;

Hughes, Timothy P. ;

Le Beau, Michelle M. ;

Pui, Ching-Hon ;

Relling, Mary V. ;

Shurtleff, Sheila A. ;

Downing, James R. .

NATURE, 2008, 453 (7191) :110-+

[30] Downregulation of γ-catenin inhibits CML cell growth and potentiates the response of CML cells to imatinib through β-catenin inhibition [J].

Niu, Chang-Chun ;

Zhao, Chen ;

Yang, Zhen-Dong ;

Zhang, Xiao-Li ;

Wu, Wei-Ru ;

Pan, Jing ;

Zhao, Chen ;

Li, Zhi-Qiang ;

Ding, Wei ;

Yang, Zhong ;

Si, Wei-Ke .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2013, 31 (02) :453-458

← 1 2 3 4 5 6 →