Polymer microneedles for transdermal drug delivery

被引：84
作者：
Lee, Jeong Woo [1 ]
Han, Mee-Ree [2 ,3 ]
Park, Jung-Hwan [2 ,3 ]
机构：
[1] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA
[2] Gachon Univ, Dept BioNano Technol, Songnam, Gyeonggi Do, South Korea
[3] Gachon Univ, Gachon BioNano Res Inst, Songnam, Gyeonggi Do, South Korea
来源：
JOURNAL OF DRUG TARGETING | 2013年 / 21卷 / 03期
基金：
美国国家卫生研究院; 新加坡国家研究基金会;
关键词：
Microneedle; polymer; biodegradable; dissolving; transdermal drug delivery; microfabrication; SELF-DISSOLVING MICROPILES; PERCUTANEOUS-ABSORPTION; ASCORBIC-ACID; RAT SKIN; ARRAY; FABRICATION; INFLUENZA; INSULIN; NEEDLES; BIOAVAILABILITY;
D O I：
10.3109/1061186X.2012.741136
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A microneedle system has been developed to deliver chemical and biological agents through the stratum corneum, which is the main barrier to drug delivery. Recently, microneedles have been fabricated from various kinds of polymers, including biocompatible polymer, biodegradable polymer, and water-soluble polymer. Polymer microneedles offer the benefits of ease of fabrication, cost-effectiveness, and mass production, as well as controlled drug release using the water solubility and degradation properties of polymer. In this review, the key features of polymer microneedles are discussed, including fabrication, materials, mechanical properties, drug delivery properties, and applications. Polymer microneedles provide a promising method for transdermal drug delivery by utilizing various physical and chemical properties of polymer.
引用
收藏
页码：211 / 223
页数：13
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