Transcriptional and epigenetic regulations of embryonic stem cells

被引：20
|
作者：
Ng, Jia-Hui [1 ]
Heng, Jian-Chien Dominic [1 ]
Loh, Yuin-Han [1 ]
Ng, Huck-Hui [1 ,2 ]
机构：
[1] Genome Inst Singapore, Gene Regulat Lab, Singapore 138672, Singapore
[2] Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore
来源：
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2008年 / 647卷 / 1-2期
关键词：
Pluripotency; Self-renewal; Embryonic stem cell; Transcriptional regulatory network; Epigenetics;
D O I：
10.1016/j.mrfmmm.2008.08.009
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Embryonic stem cells (ESCs) are characterized by their broad developmental potential and the capacity to self-renew. The advent of high-throughput technologies has facilitated genome-wide studies of transcriptional network, resulting in an ever-increasing repertoire of transcription factors implicated in the maintenance of the embryonic stem cell state. While the transcriptional circuitry continues to expand, epigenetic regulation has also gained attention as an important process in stem cell function. Herein, we discuss the recent advancements made in understanding the transcriptional and epigenetic regulations of embryonic stem cells. (c) 2008 Published by Elsevier B.V.
引用
收藏
页码：52 / 58
页数：7
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