Transcriptional and epigenetic regulations of embryonic stem cells

被引：20
|
作者：
Ng, Jia-Hui [1 ]
Heng, Jian-Chien Dominic [1 ]
Loh, Yuin-Han [1 ]
Ng, Huck-Hui [1 ,2 ]
机构：
[1] Genome Inst Singapore, Gene Regulat Lab, Singapore 138672, Singapore
[2] Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore
来源：
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2008年 / 647卷 / 1-2期
关键词：
Pluripotency; Self-renewal; Embryonic stem cell; Transcriptional regulatory network; Epigenetics;
D O I：
10.1016/j.mrfmmm.2008.08.009
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Embryonic stem cells (ESCs) are characterized by their broad developmental potential and the capacity to self-renew. The advent of high-throughput technologies has facilitated genome-wide studies of transcriptional network, resulting in an ever-increasing repertoire of transcription factors implicated in the maintenance of the embryonic stem cell state. While the transcriptional circuitry continues to expand, epigenetic regulation has also gained attention as an important process in stem cell function. Herein, we discuss the recent advancements made in understanding the transcriptional and epigenetic regulations of embryonic stem cells. (c) 2008 Published by Elsevier B.V.
引用
收藏
页码：52 / 58
页数：7
相关论文
共 50 条
  • [21] Transcriptional control of embryonic and induced pluripotent stem cells
    Guenther, Matthew G.
    EPIGENOMICS, 2011, 3 (03) : 323 - 343
  • [22] An extended transcriptional network for pluripotency of embryonic stem cells
    Kim, Jonghwan
    Chu, Jianlin
    Shen, Xiaohua
    Wang, Jianlong
    Orkin, Stuart H.
    CELL, 2008, 132 (06) : 1049 - 1061
  • [23] Stemness: Transcriptional profiling of embryonic and adult stem cells
    Ramalho-Santos, M
    Yoon, S
    Matsuzaki, Y
    Mulligan, RC
    Melton, DA
    SCIENCE, 2002, 298 (5593) : 597 - 600
  • [24] Epigenetic basis for the differentiation potential of mesenchymal and embryonic stem cells
    Collas, Philippe
    Noer, Agate
    Sorensen, Anita L.
    TRANSFUSION MEDICINE AND HEMOTHERAPY, 2008, 35 (03) : 205 - 215
  • [25] Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
    Jebeniani, Imen
    Leschik, Julia
    Puceat, Michel
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2016, (112):
  • [26] Driven Hematopoietic Differentiation of Embryonic Stem Cells: Epigenetic Perspectives
    Tesarova, Lenka
    Stejskal, Stanislav
    Koutna, Irena
    CURRENT PHARMACEUTICAL DESIGN, 2014, 20 (11) : 1674 - 1686
  • [27] Human embryonic stem cells have a unique epigenetic signature
    Bibikova, Marina
    Chudin, Eugene
    Wu, Bonnie
    Zhou, Lixin
    Garcia, Eliza Wickham
    Liu, Ying
    Shin, Soojung
    Plaia, Todd W.
    Auerbach, Jonathan M.
    Arking, Dan E.
    Gonzalez, Rodolfo
    Crook, Jeremy
    Davidson, Bruce
    Schulz, Thomas C.
    Robins, Allan
    Khanna, Aparna
    Sartipy, Peter
    Hyllner, Johan
    Vanguri, Padmavathy
    Savant-Bhonsale, Smita
    Smith, Alan K.
    Chakravarti, Aravinda
    Maitra, Anirban
    Rao, Mahendra
    Barker, David L.
    Loring, Jeanne F.
    Fan, Jian-Bing
    GENOME RESEARCH, 2006, 16 (09) : 1075 - 1083
  • [28] Directed differentiation of embryonic stem cells: Genetic and epigenetic methods
    O'Shea, KS
    WOUND REPAIR AND REGENERATION, 2001, 9 (06) : 443 - 459
  • [29] Epigenetic Control of Retrotransposon Expression in Human Embryonic Stem Cells
    Macia, Angela
    Munoz-Lopez, Martin
    Luis Cortes, Jose
    Hastings, Robert K.
    Morell, Santiago
    Lucena-Aguilar, Gema
    Antonio Marchal, Juan
    Badge, Richard M.
    Luis Garcia-Perez, Jose
    MOLECULAR AND CELLULAR BIOLOGY, 2011, 31 (02) : 300 - 316
  • [30] Epigenetic toxicity of heavy metals - implications for embryonic stem cells
    Kim, Nicholas
    Filipovic, David
    Bhattacharya, Sudin
    Cuddapah, Suresh
    ENVIRONMENT INTERNATIONAL, 2024, 193
12345