Neuraminidase inhibitors as anti-influenza virus agents

被引：64

作者：

Kim, CU ^{[1
]}

Chen, XW ^{[1
]}

Mendel, DB ^{[1
]}

机构：

[1] Gilead Sci Inc, Foster City, CA 94404 USA

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1999年 / 10卷 / 04期

关键词：

influenza; neuraminidase; inhibitors; GS; 4104; zanamivir;

D O I：

10.1177/095632029901000401

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Influenza virus neuraminidase (NA) catalyses the cleavage of sialic acid residues terminally linked to glycoproteins and glycolipids and plays an important role in the replication of the virus. Recently. several potent NA inhibitors have been synthesized based on the rational design of mimicking the transition state of the sialic acid cleavage. Zanamivir and oseltamivir (GS 4104. the prodrug of GS 4071) have emerged as promising influenza NA inhibitors for the treatment and prophylaxis of human influenza virus infection. This review describes the recent work toward the discovery and development of influenza NA inhibitors.

引用

收藏

页码：141 / 154

页数：14

相关论文

共 55 条

[1] SYNTHESIS OF 6-CARBON, 7-CARBON AND 8-CARBON SUGAR ANALOGS OF POTENT ANTIINFLUENZA 2,3-DIDEHYDRO-2,3-DIDEOXY-N-ACETYLNEURAMINIC ACID-DERIVATIVES [J].

BAMFORD, MJ ;

PICHEL, JC ;

HUSMAN, W ;

PATEL, B ;

STORER, R ;

WEIR, NG .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1995, (09) :1181-1187

[2] Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en [J].

Blick, TJ ;

Tiong, T ;

Sahasrabudhe, A ;

Varghese, JN ;

Colman, PM ;

Hart, GJ ;

Bethell, RC ;

McKimmBreschkin, JL .

VIROLOGY, 1995, 214 (02) :475-484

[3] 3-DIMENSIONAL STRUCTURE OF INFLUENZA-A N9 NEURAMINIDASE AND ITS COMPLEX WITH THE INHIBITOR 2-DEOXY 2,3-DEHYDRO-N-ACETYL NEURAMINIC ACID [J].

BOSSARTWHITAKER, P ;

CARSON, M ;

BABU, YS ;

SMITH, CD ;

LAVER, WG ;

AIR, GM .

JOURNAL OF MOLECULAR BIOLOGY, 1993, 232 (04) :1069-1083

[4] THE 2.2-A RESOLUTION CRYSTAL-STRUCTURE OF INFLUENZA-B NEURAMINIDASE AND ITS COMPLEX WITH SIALIC-ACID [J].

BURMEISTER, WP ;

RUIGROK, RWH ;

CUSACK, S .

EMBO JOURNAL, 1992, 11 (01) :49-56

[5] Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design [J].

Chand, P ;

Babu, YS ;

Bantia, S ;

Chu, NM ;

Cole, LB ;

Kotian, PL ;

Laver, WG ;

Montgomery, JA ;

Pathak, VP ;

Petty, SL ;

Shrout, DP ;

Walsh, DA ;

Walsh, GW .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (25) :4030-4052

[6] A single sequence change destabilizes the influenza virus neuraminidase tetramer [J].

Colacino, JM ;

Chirgadze, NY ;

Garman, E ;

Murti, KG ;

Loncharich, RJ ;

Baxter, AJ ;

Staschke, KA ;

Laver, WG .

VIROLOGY, 1997, 236 (01) :66-75

[7] INFLUENZA-VIRUS NEURAMINIDASE - STRUCTURE, ANTIBODIES, AND INHIBITORS [J].

COLMAN, PM .

PROTEIN SCIENCE, 1994, 3 (10) :1687-1696

[8]

COUCH RB, 1996, OPTIONS CONTROL INFL, V3, P97

[9] Recent advances in sialidase inhibitors [J].

Dowle, MD ;

Howes, PD .

EXPERT OPINION ON THERAPEUTIC PATENTS, 1998, 8 (11) :1461-1478

[10] Penetration of GS4071, a novel influenza neuraminidase inhibitor, into rat bronchoalveolar lining fluid following oral administration of the prodrug GS4104 [J].

Eisenberg, EJ ;

Bidgood, A ;

Cundy, KC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (09) :1949-1952

← 1 2 3 4 5 6 →