Environmentally Friendly Preparation of 3,4-Dihydropyrimidin-2(1H)-thiones Catalyzed by Al(H2PO4)3

被引：11

作者：

Shaterian, Hamid Reza ^{[1
]}

Hosseinian, Asghar ^{[1
]}

Ghashang, Majid ^{[1
]}

机构：

[1] Univ Sistan & Baluchestan, Dept Chem, Fac Sci, Zahedan, Iran

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2009年 / 184卷 / 01期

关键词：

Al(H2PO4)(3); Biginelli reaction; 3,4-dihydropyrimidin-2(1H)-thione; heterogeneous catalyst; multicomponent reaction; ONE-POT SYNTHESIS; CALCIUM-CHANNEL BLOCKERS; ADRENOCEPTOR-SELECTIVE ANTAGONISTS; BIGINELLI REACTION; ACID-ESTERS; DIHYDROPYRIMIDINONES; EFFICIENT; CONDENSATION; PHOSPHATES; DESIGN;

D O I：

10.1080/10426500802080576

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient, facile, simple, and green synthetic protocol for the Biginelli reaction has been developed for the preparation of 3,4-dihydropyrimidin-2(1H)-thione derivatives under thermal and microwave irradiation, solvent-free conditions, in the presence of aluminum hydrogen phosphate, Al(H2PO4)3, as an environmentally friendly heterogeneous recyclable catalyst, in high to excellent yields and short reaction time. In addition, the catalyst could be easily recovered from the reaction mixture by simple filtration and reused several times without any loss of activity.

引用

页码：126 / 134

页数：9

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