Preparation and Characterization of Dual Phase Transition Oral Hydrogel for Sustained Release of Epirubicin

被引：14
|
作者：
Lin, Hong-Ru [1 ]
Hsu, Chin-Yu [2 ]
Lo, Yu-Li [2 ]
机构：
[1] Southern Taiwan Univ Sci & Technol, Dept Chem & Mat Engn, Tainan, Taiwan
[2] Natl Univ Tainan, Dept Biol Sci & Technol, Tainan 70005, Taiwan
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2013年 / 62卷 / 14期
关键词：
Epirubicin; hydrogel; in situ gelling; oral administration; pH-sensitive; thermo-responsive; POLY(ACRYLIC ACID) MICROGELS; IN-VIVO EVALUATION; BLOCK-COPOLYMERS; CANCER-TREATMENT; DRUG-DELIVERY; ACRYLIC-ACID; CHITOSAN;
D O I：
10.1080/00914037.2013.769239
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
In situ gelling formulations composed of pluronic (Plu) and poly(acrylic acid) (PAA) were prepared for oral delivery the antitumor drug, epirubicin. The physicochemical properties, including swelling ratio, viscosity, and gel strength of these formulations with three different concentrations of PAA were characterized. Formulations all developed hydrogel forms and thus released epirubicin in a sustained way in vitro. The assay of the formulations with different epirubicin concentrations on growth inhibition of CT-26 (mouse colon adenocarcinoma) cells reveals cell viability % is decreased dose-dependently. This study highlights the advantages of using dual phase transition hydrogel to deliver antitumor drugs.
引用
收藏
页码：763 / 769
页数：7
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