Long-Term Prognosis Value of Paravalvular Leak and Patient-Prosthesis Mismatch following Transcatheter Aortic Valve Implantation: Insight from the France-TAVI Registry

被引：25

作者：

Deharo, Pierre ^{[1
,2
,3
]}

Leroux, Lionel ^{[4
]}

Theron, Alexis ^{[5
]}

Ferrara, Jerome ^{[1
]}

Vaillier, Antoine ^{[1
]}

Jaussaud, Nicolas ^{[5
]}

Porto, Alizee ^{[5
]}

Morera, Pierre ^{[5
]}

Gariboldi, Vlad ^{[2
,3
,5
]}

Iung, Bernard ^{[6
]}

Lefevre, Thierry ^{[7
]}

Commeau, Philippe ^{[8
]}

Gouysse, Margaux ^{[9
]}

du Chayla, Florence ^{[9
]}

Glatt, Nicolas ^{[9
]}

Cayla, Guillaume ^{[10
]}

Le Breton, Herve ^{[11
]}

Benamer, Hakim ^{[7
]}

Beurtheret, Sylvain ^{[12
]}

Verhoye, Jean Philippe ^{[13
]}

Eltchaninoff, Helene ^{[14
]}

Gilard, Martine ^{[15
]}

Collet, Jean Philippe ^{[16
]}

Dumonteil, Nicolas ^{[17
]}

Collart, Frederic ^{[2
,3
,4
]}

Modine, Thomas ^{[4
]}

Cuisset, Thomas ^{[1
,2
,3
]}

机构：

[1] CHU Timone, Dept Cardiol, F-13385 Marseille, France

[2] Aix Marseille La Timone Univ, INSERM, INRA, C2VN, F-13005 Marseille, France

[3] Aix Marseille Univ, Fac Med, F-13005 Marseille, France

[4] CHU Bordeaux, Dept Cardiol, F-33075 Bordeaux, France

[5] CHU Timone, Dept Chirurg Cardiaque, F-13005 Marseille, France

[6] Univ Paris Cite, Bichat Hosp, AP HP, INSERM 1148,Cardiol Dept, 46 Rue Henri Huchard, F-75018 Paris, France

[7] Hop Prive Jacques Cartier, 6 Av Noyer Lambert, F-91300 Massy, France

[8] Polyclin Fleurs, Grp ELSAN, Cardiol Intervent, F-83190 Ollioules, France

[9] Clinityx, F-78620 Acheres, France

[10] CHU Nimes, Dept Cardiol, F-30029 Nimes, France

[11] CHU Rennes, Serv Cardiol, Hop Pontchaillou, F-35033 Rennes, France

[12] St Joseph Hosp, F-13000 Marseille, France

[13] Rennes Univ Hosp, F-35033 Rennes, France

[14] CHU Rouen, Dept Cardiol, Normandie Univ, UNIROUEN,U1096, F-76000 Rouen, France

[15] CHRU Brest, Dept Cardiol, F-29200 Brest, France

[16] Sorbonne Univ, Dept Cardiol, Pitie Salpetriere, AP HP,INSERM,UMRS 1166, F-75000 Paris, France

[17] Clin Pasteur, Grp CardioVasc Interventionnel, F-31300 Toulouse, France

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 20期

关键词：

TAVI; mismatch; paravalvular leak; EUROPEAN ASSOCIATION; AMERICAN SOCIETY; HEART-VALVES; REPLACEMENT; OUTCOMES; ECHOCARDIOGRAPHY; RECOMMENDATIONS; REGURGITATION; PREDICTORS;

D O I：

10.3390/jcm11206117

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Transcatheter aortic valve implantation (TAVI) is the preferred treatment for symptomatic severe aortic stenosis (AS) in a majority of patients across all surgical risks. Patients and methods: Paravalvular leak (PVL) and patient-prosthesis mismatch (PPM) are two frequent complications of TAVI. Therefore, based on the large France-TAVI registry, we planned to report the incidence of both complications following TAVI, evaluate their respective risk factors, and study their respective impacts on long-term clinical outcomes, including mortality. Results: We identified 47,494 patients in the database who underwent a TAVI in France between 1 January 2010 and 31 December 2019. Within this population, 17,742 patients had information regarding PPM status (5138 with moderate-to-severe PPM, 29.0%) and 20,878 had information regarding PVL (4056 with PVL >= 2, 19.4%). After adjustment, the risk factors for PVL >= 2 were a lower body mass index (BMI), a high baseline mean aortic gradient, a higher body surface area, a lower ejection fraction, a smaller diameter of TAVI, and a self-expandable TAVI device, while for moderate-to-severe PPM we identified a younger age, a lower BMI, a larger body surface area, a low aortic annulus area, a low ejection fraction, and a smaller diameter TAVI device (OR 0.85; 95% CI, 0.83-0.86) as predictors. At 6.5 years, PVL >= 2 was an independent predictor of mortality and was associated with higher mortality risk. PPM was not associated with increased risk of mortality. Conclusions: Our analysis from the France-TAVI registry showed that both moderate-to-severe PPM and PVL >= 2 continue to be frequently observed after the TAVI procedure. Different risk factors, mostly related to the patient's anatomy and TAVI device selection, for both complications have been identified. Only PVL >= 2 was associated with higher mortality during follow-up.

引用

页数：19

共 26 条

[1] Comparison of Balloon-Expandable vs Self-expandable Valves in Patients Undergoing Transcatheter Aortic Valve Replacement The CHOICE Randomized Clinical Trial [J].

Abdel-Wahab, Mohamed ;

Mehilli, Julinda ;

Frerker, Christian ;

Neumann, Franz-Josef ;

Kurz, Thomas ;

Toelg, Ralph ;

Zachow, Dirk ;

Guerra, Elena ;

Massberg, Steffen ;

Schaefer, Ulrich ;

El-Mawardy, Mohamed ;

Richardt, Gert .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2014, 311 (15) :1503-1514

[2] Temporal Trends in Transcatheter Aortic Valve Replacement in France FRANCE 2 to FRANCE TAVI [J].

Auffret, Vincent ;

Lefevre, Thierry ;

Van Belle, Eric ;

Eltchaninoff, Helene ;

Iung, Bernard ;

Koning, Rene ;

Motreff, Pascal ;

Leprince, Pascal ;

Verhoye, Jean Philippe ;

Manigold, Thibaut ;

Souteyrand, Geraud ;

Boulmier, Dominique ;

Joly, Patrick ;

Pinaud, Frederic ;

Himbert, Dominique ;

Collet, Jean Philippe ;

Rioufol, Gilles ;

Ghostine, Said ;

Bar, Olivier ;

Dibie, Alain ;

Champagnac, Didier ;

Leroux, Lionel ;

Collet, Frederic ;

Teiger, Emmanuel ;

Darremont, Olivier ;

Folliguet, Thierry ;

Leclercq, Florence ;

Lhermusier, Thibault ;

Olhmann, Patrick ;

Huret, Bruno ;

Lorgis, Luc ;

Drogoul, Laurent ;

Bertrand, Bernard ;

Spaulding, Christian ;

Quilliet, Laurent ;

Cuisset, Thomas ;

Delomez, Maxence ;

Beygui, Farzin ;

Claudel, Jean-Philippe ;

Hepp, Alain ;

Jegou, Arnaud ;

Gommeaux, Antoine ;

Mirode, Anfani ;

Christiaens, Luc ;

Christophe, Charles ;

Cassat, Claude ;

Metz, Damien ;

Mangin, Lionel ;

Isaaz, Karl ;

Jacquemin, Laurent .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2017, 70 (01) :42-55

[3] STS-ACC TVT Registry of Transcatheter Aortic Valve Replacement [J].

Carroll, John D. ;

Mack, Michael J. ;

Vemulapalli, Sreekanth ;

Herrmann, Howard C. ;

Gleason, Thomas G. ;

Hanzel, George ;

Deeb, G. Michael ;

Thourani, Vinod H. ;

Cohen, David J. ;

Desai, Nimesh ;

Kirtane, Ajay J. ;

Fitzgerald, Susan ;

Michaels, Joan ;

Krohn, Carole ;

Masoudi, Frederick A. ;

Brindis, Ralph G. ;

Bavaria, Joseph E. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 76 (21) :2492-2516

[4] Impact of Sapien 3 Balloon-Expandable Versus Evolut R Self-Expandable Transcatheter Aortic Valve Implantation in Patients With Aortic Stenosis Data From a Nationwide Analysis [J].

Deharo, Pierre ;

Bisson, Arnaud ;

Herbert, Julien ;

Lacour, Thibaud ;

Saint Etienne, Christophe ;

Grammatico-Guillon, Leslie ;

Porto, Alizee ;

Collart, Frederic ;

Bourguignon, Thierry ;

Cuisset, Thomas ;

Fauchier, Laurent .

CIRCULATION, 2020, 141 (04) :260-268

[5] Successful linkage of French large-scale national registry populations to national reimbursement data: Improved data completeness and minimized loss to follow-up [J].

Didier, Romain ;

Gouysse, Margaux ;

Eltchaninoff, Helene ;

Le Breton, Herve ;

Commeau, Philippe ;

Cayla, Guillaume ;

Glatt, Nicolas ;

Glatt, Bernard ;

Gabbas, Mehdi ;

Tuppin, Philippe ;

Liepchitz, Laura ;

Boussac, Marjorie ;

Iung, Bernard ;

Gilard, Martine .

ARCHIVES OF CARDIOVASCULAR DISEASES, 2020, 113 (8-9) :534-541

[6] 2-Year Outcomes After Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients [J].

Forrest, John K. ;

Deeb, G. Michael ;

Yakubov, Steven J. ;

Rovin, Joshua D. ;

Mumtaz, Mubashir ;

Gada, Hemal ;

O'Hair, Daniel ;

Bajwa, Tanvir ;

Sorajja, Paul ;

Heiser, John C. ;

Merhi, William ;

Mangi, Abeel ;

Spriggs, Douglas J. ;

Kleiman, Neal S. ;

Chetcuti, Stanley J. ;

Teirstein, Paul S. ;

Zorn, George L., III ;

Tadros, Peter ;

Tchetche, Didier ;

Resar, Jon R. ;

Walton, Antony ;

Gleason, Thomas G. ;

Ramlawi, Basel ;

Iskander, Ayman ;

Caputo, Ronald ;

Oh, Jae K. ;

Huang, Jian ;

Reardon, Michael J. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2022, 79 (09) :882-896

[7] Valve Academic Research Consortium 3: Updated Endpoint Definitions for Aortic Valve Clinical Research [J].

Genereux, Philippe ;

Piazza, Nicolo ;

Alu, Maria C. ;

Nazif, Tamim ;

Hahn, Rebecca T. ;

Pibarot, Philippe ;

Bax, Jeroen J. ;

Leipsic, Jonathon A. ;

Blanke, Philipp ;

Blackstone, Eugene H. ;

Finn, Matthew T. ;

Kapadia, Samir ;

Linke, Axel ;

Mack, Michael J. ;

Makkar, Raj ;

Mehran, Roxana ;

Popma, Jeffrey J. ;

Reardon, Michael ;

Rodes-Cabau, Josep ;

Van Mieghem, Nicolas M. ;

Webb, John G. ;

Cohen, David J. ;

Leon, Martin B. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 77 (21) :2717-2746

[8] Late Outcomes of Transcatheter Aortic Valve Replacement in High-Risk Patients The FRANCE-2 Registry [J].

Gilard, Martine ;

Eltchaninoff, Helene ;

Donzeau-Gouge, Patrick ;

Chevreul, Karine ;

Fajadet, Jean ;

Leprince, Pascal ;

Leguerrier, Alain ;

Lievre, Michel ;

Prat, Alain ;

Teiger, Emmanuel ;

Lefevre, Thierry ;

Tchetche, Didier ;

Carrie, Didier ;

Himbert, Dominique ;

Albat, Bernard ;

Cribier, Alain ;

Sudre, Arnaud ;

Blanchard, Didier ;

Rioufol, Gilles ;

Collet, Frederic ;

Houel, Remi ;

Dos Santos, Pierre ;

Meneveau, Nicolas ;

Ghostine, Said ;

Manigold, Thibaut ;

Guyon, Philippe ;

Grisoli, Dominique ;

Le Breton, Herve ;

Delpine, Stephane ;

Didier, Romain ;

Favereau, Xavier ;

Souteyrand, Geraud ;

Ohlmann, Patrick ;

Doisy, Vincent ;

Grollier, Gilles ;

Gommeaux, Antoine ;

Claudel, Jean-Philippe ;

Bourlon, Francois ;

Bertrand, Bernard ;

Laskar, Marc ;

Iung, Bernard .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 68 (15) :1637-1647

[9] Registry of Transcatheter Aortic-Valve Implantation in High-Risk Patients [J].

Gilard, Martine ;

Eltchaninoff, Helene ;

Iung, Bernard ;

Donzeau-Gouge, Patrick ;

Chevreul, Karine ;

Fajadet, Jean ;

Leprince, Pascal ;

Leguerrier, Alain ;

Lievre, Michel ;

Prat, Alain ;

Teiger, Emmanuel ;

Lefevre, Thierry ;

Himbert, Dominique ;

Tchetche, Didier ;

Carrie, Didier ;

Albat, Bernard ;

Cribier, Alain ;

Rioufol, Gilles ;

Sudre, Arnaud ;

Blanchard, Didier ;

Collet, Frederic ;

Dos Santos, Pierre ;

Meneveau, Nicolas ;

Tirouvanziam, Ashok ;

Caussin, Christophe ;

Guyon, Philippe ;

Boschat, Jacques ;

Le Breton, Herve ;

Collart, Frederic ;

Houel, Remi ;

Delpine, Stephane ;

Souteyrand, Geraud ;

Favereau, Xavier ;

Ohlmann, Patrick ;

Doisy, Vincent ;

Grollier, Gilles ;

Gommeaux, Antoine ;

Claudel, Jean-Philippe ;

Bourlon, Francois ;

Bertrand, Bernard ;

Van Belle, Eric ;

Laskar, Marc .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (18) :1705-1715

[10] Prosthesis-Patient Mismatch in Patients Undergoing Transcatheter Aortic Valve Replacement From the STS/ACC TVT Registry [J].

Herrmann, Howard C. ;

Daneshvar, Samuel A. ;

Fonarow, Gregg C. ;

Stebbins, Amanda ;

Vemulapalli, Sreekanth ;

Desai, Nimesh D. ;

Malenka, David J. ;

Thourani, Vinod H. ;

Rymer, Jennifer ;

Kosinski, Andrzej S. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018, 72 (22) :2701-2711

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