Effects of Serum n-3 to n-6 Polyunsaturated Fatty Acids Ratios on Coronary Atherosclerosis in Statin-Treated Patients With Coronary Artery Disease

被引：56

作者：

Nozue, Tsuyoshi ^{[1
]}

Yamamoto, Shingo ^{[2
]}

Tohyama, Shinichi ^{[3
]}

Fukui, Kazuki ^{[4
]}

Umezawa, Shigeo ^{[5
]}

Onishi, Yuko ^{[5
]}

Kunishima, Tomoyuki ^{[6
]}

Sato, Akira ^{[7
]}

Nozato, Toshihiro ^{[8
]}

Miyake, Shogo ^{[9
]}

Takeyama, Youichi ^{[10
]}

Morino, Yoshihiro ^{[11
]}

Yamauchi, Takao ^{[12
]}

Muramatsu, Toshiya ^{[13
]}

Hibi, Kiyoshi ^{[14
]}

Terashima, Mitsuyasu ^{[15
]}

Michishita, Ichiro ^{[1
]}

机构：

[1] Yokohama Sakae Kyosai Hosp, Dept Internal Med, Div Cardiol, Yokohama, Kanagawa, Japan

[2] Tsurumi Nishiguchi Hosp, Dept Cardiol, Yokohama, Kanagawa, Japan

[3] Yokohama Seamens Insurance Hosp, Dept Cardiol, Yokohama, Kanagawa, Japan

[4] Kanagawa Cardiovasc & Resp Ctr, Dept Cardiol, Yokohama, Kanagawa, Japan

[5] Hiratsuka Kyosai Hosp, Dept Cardiol, Hiratsuka, Kanagawa, Japan

[6] Teikyo Univ, Sch Med, Mizonokuchi Hosp, Dept Internal Med 4, Kawasaki, Kanagawa, Japan

[7] Yokosuka Kyosai Hosp, Ctr Cardiovasc, Yokosuka, Kanagawa, Japan

[8] Natl Hosp Org, Disaster Med Ctr, Dept Cardiol, Tokyo, Japan

[9] Ebina Gen Hosp, Dept Cardiol, Ebina, Kanagawa, Japan

[10] Showa Univ, Fujigaoka Rehabiritat Hosp, Div Cardiol, Yokohama, Kanagawa, Japan

[11] Tokai Univ, Sch Med, Dept Cardiol, Isehara, Kanagawa 25911, Japan

[12] Tokyo Womens Med Univ, Dept Cardiol, Tokyo, Japan

[13] Saiseikai Yokohama City Eastern Hosp, Dept Cardiol, Yokohama, Kanagawa, Japan

[14] Yokohama City Univ, Med Ctr, Div Cardiol, Yokohama, Kanagawa 232, Japan

[15] Cardiovasc Imaging Ctr, Toyohashi, Aichi, Japan

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2013年 / 111卷 / 01期

关键词：

RANDOMIZED CONTROLLED-TRIAL; INTRAVASCULAR ULTRASOUND; EICOSAPENTAENOIC ACID; FISH-OIL; HYPERCHOLESTEROLEMIC PATIENTS; CARDIOVASCULAR-DISEASE; DOCOSAHEXAENOIC ACID; PLAQUE COMPOSITION; HEART-DISEASE; INFLAMMATION;

D O I：

10.1016/j.amjcard.2012.08.038

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A low ratio of n-3 to n-6 polyunsaturated fatty acids has been associated with cardiovascular events. However, the effects of this ratio on coronary atherosclerosis have not been fully examined. The purpose of the present study was to evaluate the correlations between the n-3 to n-6 polyunsaturated fatty acid ratio and coronary atherosclerosis. Coronary atherosclerosis in nonculprit lesions in the percutaneous coronary intervention vessel was evaluated using virtual histology intravascular ultrasound in 101 patients at the time of percutaneous coronary intervention and 8 months after statin therapy. Forty-six patients (46%) showed atheroma progression and the remaining 55 patients (54%) showed atheroma regression at 8-month follow-up. Significant negative correlations were observed between percentage change in plaque volume and change in the eicosa-pentaenoic acid (EPA)/arachidonic acid (AA) ratio (r = -0.190, p = 0.05), docosa-hexaenoic acid (DHA)/AA ratio (r = -0.231, p = 0.02), and EPA + DHA/AA ratio (r = -0.240, p = 0.02). Furthermore, percentage change in the fibrous component volume was negatively and significantly correlated with change in the EPA/AA ratio (r = -0.206, p = 0.04) and EPA + DHA/AA ratio (r = -0.217, p = 0.03). Multivariate regression analysis showed that change in the EPA + DHA/AA ratio was a significant,predictor of percentage change in plaque volume and fibrous component volume (beta = -0.221, p = 0.02, and beta = -0:200, p = 0.04, respectively). In conclusion, decreases in serum n-3 to n-6 polyunsaturated fatty acid ratios are associated with progression in coronary atherosclerosis evaluated using virtual histology intravascular ultrasound in statin-treated patients with coronary artery disease. (c) 2013 Elsevier Inc. All rights reserved. (Am J Cardiol 2013;111:6-11)

引用

页码：6 / 11

页数：6

共 29 条

[1]

Aikawa M, 2001, CIRCULATION, V103, P276

[2] Impact of omega-3 polyunsaturated fatty acids on coronary plaque instability: An integrated backscatter intravascular ultrasound study [J].

Amano, Tetsuya ;

Matsubara, Tatsuaki ;

Uetani, Tadayuki ;

Kato, Masataka ;

Kato, Bunichi ;

Yoshida, Tomohiro ;

Harada, Ken ;

Kumagai, Soichiro ;

Kunimura, Ayako ;

Shinbo, Yusaku ;

Kitagawa, Katsuhide ;

Ishii, Hideki ;

Murohara, Toyoaki .

ATHEROSCLEROSIS, 2011, 218 (01) :110-116

[3] n-3 polyunsaturated fatty acids and inflammation: From molecular biology to the clinic [J].

Calder, PC .

LIPIDS, 2003, 38 (04) :343-352

[4] n-3 fatty acids and cardiovascular disease: evidence explained and mechanisms explored [J].

Calder, PC .

CLINICAL SCIENCE, 2004, 107 (01) :1-11

[5] n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases [J].

Calder, Philip C. .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2006, 83 (06) :1505S-1519S

[6] Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability [J].

Cawood, Abbie L. ;

Ding, Ren ;

Napper, Frances L. ;

Young, Ruth H. ;

Williams, Jennifer A. ;

Ward, Matthew J. A. ;

Gudmundsen, Ola ;

Vige, Runar ;

Payne, Simon P. K. ;

Ye, Shu ;

Shearman, Ciff P. ;

Gallagher, Patrick J. ;

Grimble, Robert F. ;

Calder, Philip C. .

ATHEROSCLEROSIS, 2010, 212 (01) :252-259

[7] Effect of Intensive Statin Therapy on Regression of Coronary Atherosclerosis in Patients With Acute Coronary Syndrome A Multicenter Randomized Trial Evaluated by Volumetric Intravascular Ultrasound Using Pitavastatin Versus Atorvastatin (JAPAN-ACS [Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome] Study) [J].

Hiro, Takafumi ;

Kimura, Takeshi ;

Morimoto, Takeshi ;

Miyauchi, Katsumi ;

Nakagawa, Yoshihisa ;

Yamagishi, Masakazu ;

Ozaki, Yukio ;

Kimura, Kazuo ;

Saito, Satoshi ;

Yamaguchi, Tetsu ;

Daida, Hiroyuki ;

Matsuzaki, Masunori .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 54 (04) :293-302

[8] Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese - The Japan Public Health Center-based (JPHC) Study Cohort I [J].

Iso, H ;

Kobayashi, M ;

Ishihara, J ;

Sasaki, S ;

Okada, K ;

Kita, Y ;

Kokubo, Y ;

Tsugane, S .

CIRCULATION, 2006, 113 (02) :195-202

[9] Effects of diet and simvastatin on fatty acid composition in hypercholesterolemic men -: A randomized controlled trial [J].

Jula, A ;

Marniemi, J ;

Rönnemaa, T ;

Virtanen, A ;

Huupponen, R .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (09) :1952-1959

[10] Relationship Between Coronary Plaque Vulnerability and Serum n-3/n-6 Polyunsaturated Fatty Acid Ratio [J].

Kashiyama, Toshikazu ;

Ueda, Yasunori ;

Nemoto, Takayoshi ;

Wada, Mitsuru ;

Masumura, Yuki ;

Matsuo, Koshi ;

Nishio, Mayu ;

Hirata, Akio ;

Asai, Mitsutoshi ;

Kashiwase, Kazunori ;

Kodama, Kazuhisa .

CIRCULATION JOURNAL, 2011, 75 (10) :2432-2438

← 1 2 3 →