Malignant paraganglioma of the urinary bladder: Immunohistochemical study of prognostic indicators

被引:15
作者
Kovacs, K
Bell, CD
Gardiner, GW
Honey, RJ
Goguen, J
Rotondo, F
机构
[1] Univ Toronto, St Michaels Hosp, Dept Lab Med, Toronto, ON M5B 1W8, Canada
[2] Univ Toronto, St Michaels Hosp, Dept Urol, Toronto, ON M5B 1W8, Canada
[3] Univ Toronto, St Michaels Hosp, Dept Endocrinol, Toronto, ON M5B 1W8, Canada
关键词
extra-adrenal paraganglioma; immunohistochemistry; pathology; prognosis; urinary bladder neoplasms;
D O I
10.1385/EP:16:4:363
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Using various immunohistochemical markers, the objective of our study was to assess whether correlation exists between growth potential of paraganglioma (pheochromocytoma) cells and formation of metastasis. The patient was a 28-yr-old man who presented with intermittent episodes of gross hematuria due to a mass in the urinary bladder. He had no constitutional symptoms to suggest paraganglioma. Histologic, immunohistochemical, and electron microscopic investigation of the surgically removed tissue proved that the tumor was a malignant paraganglioma with metastases in the regional lymph nodes. The immunohistochemical tests were not supportive of high cell proliferation index, indicating that metastases can develop in the absence of rapid multiplication of the tumor cells. Abnormalities in vascular architecture and marked expression of VEGF in the tumor cells may be regarded as prognostic signs to predict the formation of metastases.
引用
收藏
页码:363 / 369
页数:7
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