The role of nucleocytoplasmic transport in mechanotransduction

被引：29

作者：

Kassianidou, Elena ^{[1
,2
]}

Kalita, Joanna ^{[1
,2
]}

Lim, Roderick Y. H. ^{[1
,2
]}

机构：

[1] Univ Basel, Biozentrum, Klingelbergstr 70, CH-4056 Basel, Switzerland

[2] Univ Basel, Swiss Nanosci Inst, Klingelbergstr 70, CH-4056 Basel, Switzerland

来源：

EXPERIMENTAL CELL RESEARCH | 2019年 / 377卷 / 1-2期

基金：

瑞士国家科学基金会;

关键词：

NUCLEAR-PORE COMPLEX; HIPPO PATHWAY; INDEPENDENT PATHWAY; LOCALIZATION SIGNAL; IMPORTIN-BETA; CELL CONTACT; ACTIN; TRANSLOCATION; FORCE; TISSUE;

D O I：

10.1016/j.yexcr.2019.02.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cells integrate mechanical and biochemical signals via a process called mechanotransduction to generate essential gene expression patterns in space and time. This is vital for cell migration and proliferation as well as tissue morphogenesis and remodeling. While the force-sensing and force-transducing mechanisms are generally known, it remains unclear how mechanoresponsive transcription factors (TFs) are selectively translocated into the nucleus upon force activation. Such TFs include Yes-Associated Protein (YAP), Myocardin Related Transcription Factors (MRTFs), Hypoxia Induced Factors (HIFs) and others. Here, we discuss how the nucleocytoplasmic transport machinery intersects with mechanoresponsive TFs to facilitate their selective transport through nuclear pore complexes.

引用

页码：86 / 93

页数：8

共 79 条

[71]

Wolf C. B., 2009, CELLULAR MECHANOTRAN, P417

[72] Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFβ signaling complexes in the cytoplasm and nucleus [J].