Recycling side-effects into clinical markers for drug repositioning

被引：31

作者：

Duran-Frigola, Miquel ^{[1
]}

Aloy, Patrick ^{[1
,2
]}

机构：

[1] Inst Res Biomed IRB Barcelona, Joint IRB BSC Program Computat Biol, Barcelona 08028, Spain

[2] ICREA, Barcelona 08010, Spain

来源：

GENOME MEDICINE | 2012年 / 4卷

关键词：

Side effects; drug repositioning; polypharmacology; mechanism of action;

D O I：

10.1186/gm302

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Side-effects are the unintended consequence of therapeutic treatments, but they can also be seen as valuable read-outs of drug effects in humans; these effects are difficult to infer or predict from pre-clinical models. Indeed, some studies suggest that drugs with similar side-effect profiles may also share therapeutic properties through related mechanisms of action. A recent publication exploits this concept to systematically investigate new indications for already marketed drugs, and presents a strategy to get the most out of the tiny portion of chemicals that have proved to be effective and safe.

引用

页数：4

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