P(NMe2)3-mediated reductive [1+4] annulation of isatins with enones: a facile synthesis of spirooxindole-dihydrofurans

被引：63

作者：

Zhou, Rong ^{[1
]}

Zhang, Kai ^{[1
]}

Chen, Yusong ^{[1
]}

Meng, Qiang ^{[1
]}

Liu, Yiyi ^{[2
]}

Li, Ruifeng ^{[1
]}

He, Zhengjie ^{[2
,3
]}

机构：

[1] Taiyuan Univ Technol, Coll Chem & Chem Engn, Taiyuan 030024, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

[3] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 78期

基金：

中国国家自然科学基金;

关键词：

CATALYTIC ASYMMETRIC-SYNTHESIS; ALPHA-KETO ESTERS; DIASTEREOSELECTIVE SYNTHESIS; SPIROCYCLIC OXINDOLES; CONSTRUCTION; CONDENSATION; DERIVATIVES; CYCLOADDITION; DIKETONES; ALKALOIDS;

D O I：

10.1039/c5cc03676c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel P(NMe2)(3)-mediated reductive [1+4] annulation reaction between isatins and enones has been developed, providing the facile synthesis of spirooxindole-dihydrofurans. This reaction unveils the first practical approach to construct five-membered cyclic motifs via a Kukhtin-Ramirez adduct involved [1+4] annulation mode.

引用

页码：14663 / 14666

页数：4

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