Frizzled and LRP5/6 Receptors for Wnt/β-Catenin Signaling

被引：420

作者：

MacDonald, Bryan T.

He, Xi ^{[1
]}

机构：

[1] Boston Childrens Hosp, FM Kirby Neurobiol Ctr, Boston, MA 02115 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2012年 / 4卷 / 12期

基金：

美国国家卫生研究院;

关键词：

SYNTHASE KINASE 3-BETA; PLANAR CELL POLARITY; ADENOMATOUS POLYPOSIS-COLI; DISHEVELLED DEP DOMAIN; BETA-CATENIN; STRUCTURAL BASIS; NEGATIVE REGULATOR; DIX DOMAIN; SUBSTRATE-SPECIFICITY; PLASMA-MEMBRANE;

D O I：

10.1101/cshperspect.a007880

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of cytoplasmic beta-catenin. In this study, we review the current knowledge of these two families of receptors, including their structures and interactions with Wnt proteins, and signaling mechanisms from receptor activation to the engagement of intracellular partners Dishevelled and Axin, and finally to the inhibition of beta-catenin phosphorylation and ensuing beta-catenin stabilization.

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页数：23

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共 162 条

[1] Structure and expression of conserved Wnt pathway components in the demosponge Amphimedon queenslandica [J].

Adamska, Maja ;

Larroux, Claire ;

Adamski, Marcin ;

Green, Kathryn ;

Lovas, Erica ;

Koop, Demian ;

Richards, Gemma S. ;

Zwafink, Christin ;

Degnan, Bernard M. .

EVOLUTION & DEVELOPMENT, 2010, 12 (05) :494-518

[2] Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6 [J].

Ahn, Victoria E. ;

Chu, Matthew Ling-Hon ;

Choi, Hee-Jung ;

Tran, Denise ;

Abo, Arie ;

Weis, William I. .

DEVELOPMENTAL CELL, 2011, 21 (05) :862-873

[3] Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP [J].

Ahumada, A ;

Slusarski, DC ;

Liu, XX ;

Moon, RT ;

Malbon, CC ;

Wang, HY .

SCIENCE, 2002, 298 (5600) :2006-2010

[4] Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways [J].

Axelrod, JD ;

Miller, JR ;

Shulman, JM ;

Moon, RT ;

Perrimon, N .

GENES & DEVELOPMENT, 1998, 12 (16) :2610-2622

[5] Wingless/Wnt signal transduction requires distinct initiation and amplification steps that both depend on Arrow/LRP [J].

Baig-Lewis, Shahana ;

Peterson-Nedry, Wynne ;

Wehrli, Marcel .

DEVELOPMENTAL BIOLOGY, 2007, 306 (01) :94-111

[6] Pointing in the right direction: new developments in the field of planar cell polarity [J].

Bayly, Roy ;

Axelrod, Jeffrey D. .

NATURE REVIEWS GENETICS, 2011, 12 (06) :385-391

[7] Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β [J].

Behrens, J ;

Jerchow, BA ;

Würtele, M ;

Grimm, J ;

Asbrand, C ;

Wirtz, R ;

Kühl, M ;

Wedlich, D ;

Birchmeier, W .

SCIENCE, 1998, 280 (5363) :596-599

[8] A new member of the frizzled family from Drosophila functions as a Wingless receptor [J].

Bhanot, P ;

Brink, M ;

Samos, CH ;

Hsieh, JC ;

Wang, YS ;

Macke, JP ;

Andrew, D ;

Nathans, J ;

Nusse, R .

NATURE, 1996, 382 (6588) :225-230

[9] Wnt/β-Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma [J].

Biechele, Travis L. ;

Kulikauskas, Rima M. ;

Toroni, Rachel A. ;

Lucero, Olivia M. ;

Swift, Reyna D. ;

James, Richard G. ;

Robin, Nick C. ;

Dawson, David W. ;

Moon, Randall T. ;

Chien, Andy J. .

SCIENCE SIGNALING, 2012, 5 (206)

[10] Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation [J].

Bilic, Josipa ;

Huang, Ya-Lin ;

Davidson, Gary ;

Zimmermann, Timo ;

Cruciat, Cristina-Maria ;

Bienz, Mariann ;

Niehrs, Christof .

SCIENCE, 2007, 316 (5831) :1619-1622

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