Bone marrow-derived endothelial progenitor cells are involved in aneurysm repair in rabbits

被引：25

作者：

Fang, Xinggen ^{[1
,2
]}

Zhao, Rui ^{[1
]}

Wang, Kuizhong ^{[1
]}

Li, Zifu ^{[1
]}

Yang, Penfei ^{[1
]}

Huang, Qinghai ^{[1
]}

Xu, Yi ^{[1
]}

Hong, Bo ^{[1
]}

Liu, Jianmin ^{[1
]}

机构：

[1] Second Mil Med Univ, Changhai Hosp, Dept Neurosurg, Shanghai 200433, Peoples R China

[2] Yijishan Hosp, Wannan Med Coll, Dept Neurosurg, Wuhu, Peoples R China

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2012年 / 19卷 / 09期

关键词：

Endothelial cells; Intracranial aneurysm; Rabbit; Wound healing; NEOINTIMA FORMATION; CEREBRAL ANEURYSMS; VASCULAR INJURY; RATS; REENDOTHELIALIZATION; ANGIOGENESIS; EXPRESSION;

D O I：

10.1016/j.jocn.2011.09.038

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Endothelial progenitor cells (EPC) are believed to be involved in aneurysmal repair and remodeling. The aim of this study was to test this hypothesis and, if true, explore how EPC contribute to aneurysm repair in a rabbit model of elastase-induced carotid aneurysm. Rabbits were divided randomly into an in situ carotid EPC transfusion group (ISCT group, n = 5), and an intravenous EPC transfusion group (IVT group, n = 5). Autologous EPC were double-labeled with Hoechst 33342 and 5,6-carboxyfluorescein diacetate succinimidyl ester before injection into the animals in either the carotid artery (ISCT group) or marginal ear veins (IVT group). Three weeks later, labeled cells in the aneurysms were observed with respect: to location, adhesion, and growth to detect signs of aneurysm repair. Labeled EPC were detected within the neointima in all five aneurysms in the ISCT group and in three of the five aneurysms in the IVT group, but there was no endothelial growth in the aneurysmal neointima in either group. These results show that bone marrow-derived EPC are involved in the process of aneurysm repair in this rabbit model. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1283 / 1286

页数：4

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