Pd-catalyzed Suzuki/Sonogashira cross-coupling reaction and the direct sp3 arylation of 7-chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine

被引：22

作者：

Loubidi, Mohammed ^{[1
]}

Moutardier, Anais ^{[1
]}

Campos, Joana F. ^{[1
]}

Berteina-Raboin, Sabine ^{[1
]}

机构：

[1] Univ Orleans, Inst Organ & Analyt Chem, CNRS, UMR 7311, BP 6759,Rue Chartres, F-45067 Orleans 2, France

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 11期

关键词：

Triazolo[1,5-a]pyrimidine; Suzuki; Sonogashira; Palladium; Direct sp(3) arylation; C-C; POTENT; AGENTS; SONOGASHIRA; DESIGN; TRIAZOLOPYRIMIDINES; HETEROCYCLES; DERIVATIVES; INHIBITORS; DIVERSITY;

D O I：

10.1016/j.tetlet.2018.02.001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rapid and efficient method is reported for the synthesis of the [1,2,4]triazolo[1,5-a]pyrimidine motif. Palladium catalyzed Suzuki and Sonogashira cross coupling reactions on 7-chloro-5-methyl-(1,2,4]triazolo[1,5-a]pyrimidine were performed. The direct sp(3) arylation of compounds resulting from the Suzuki reaction was then carried out. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：1050 / 1054

页数：5

共 45 条

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[40] Regioselective Synthesis of New 2,4-(Het)aryl-3H-pyrido[1′,2′:1,5]pyrazolo[4,3-d]pyrimidines Involving Palladium-Catalyzed Cross-Coupling Reactions
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