Pd-catalyzed Suzuki/Sonogashira cross-coupling reaction and the direct sp3 arylation of 7-chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine

被引：22
|
作者：
Loubidi, Mohammed [1 ]
Moutardier, Anais [1 ]
Campos, Joana F. [1 ]
Berteina-Raboin, Sabine [1 ]
机构：
[1] Univ Orleans, Inst Organ & Analyt Chem, CNRS, UMR 7311, BP 6759,Rue Chartres, F-45067 Orleans 2, France
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 11期
关键词：
Triazolo[1,5-a]pyrimidine; Suzuki; Sonogashira; Palladium; Direct sp(3) arylation; C-C; POTENT; AGENTS; SONOGASHIRA; DESIGN; TRIAZOLOPYRIMIDINES; HETEROCYCLES; DERIVATIVES; INHIBITORS; DIVERSITY;
D O I：
10.1016/j.tetlet.2018.02.001
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A rapid and efficient method is reported for the synthesis of the [1,2,4]triazolo[1,5-a]pyrimidine motif. Palladium catalyzed Suzuki and Sonogashira cross coupling reactions on 7-chloro-5-methyl-(1,2,4]triazolo[1,5-a]pyrimidine were performed. The direct sp(3) arylation of compounds resulting from the Suzuki reaction was then carried out. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1050 / 1054
页数：5
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