Cytotoxic steroidal saponins from Ophiopogon japonicus

被引：48

作者：

Li, Ning ^{[1
]}

Zhang, Liang ^{[1
]}

Zeng, Ke-Wu ^{[1
]}

Zhou, Yuan ^{[1
]}

Zhang, Jia-Yu ^{[1
]}

Che, Yan-Yun ^{[1
]}

Tu, Peng-Fei ^{[1
]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

STEROIDS | 2013年 / 78卷 / 01期

关键词：

Ophiopogon japonicus; Steroidal saponins; Cytotoxic activity; GLYCOSIDES; TUBERS;

D O I：

10.1016/j.steroids.2012.10.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new steroidal saponins, named ophiopogonin P-S (1-4), together with eleven known ones (5-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analysis. Compounds 2-15 were evaluated for their cytotoxic activity against five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela). Compounds 2, 5, 6, 8 and 9 were cytotoxic for all cell lines tested. Compounds 7, 11 and 15 showed selective cytotoxicity against some of the cell lines. The structure-activity relationship of these compounds was discussed. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：1 / 7

页数：7

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