Glucopyranose spirohydantoins: Specific inhibitors of glycogen phosphorylase

被引：0
作者：
delaFuente, C
Krulle, TM
Watson, KA
Gregoriou, M
Johnson, LN
Tsitsanou, KE
Zographos, SE
Oikonomakos, NG
Fleet, GWJ
机构：
[1] NATL HELLEN RES FDN,ATHENS 11635,GREECE
[2] UNIV OXFORD,MOL BIOPHYS LAB,OXFORD OX1 3QU,ENGLAND
来源：
SYNLETT | 1997年 / 05期
关键词：
hydantocidin; glycogen phosphorylase; enzyme inhibition; hydantoin; lactone; ANOMERIC POSITION; GLUCOSE ANALOG; MANNOFURANOSE; STATE;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A short synthesis of the spirohydantoin of glucopyranose Ip [a potent and specific inhibitor of glycogen phosphorylase], together with its inactive anomer 1 alpha, from a readily available heptonolactone is described; this is the first synthesis of a spirohydantoin of a pyranose in which the pyranose ring is formed after the hydantoin ring.
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页码：485 / &
页数：4
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