Synthesis and anticancer activity of some novel fused pyridine ring system

被引：29

作者：

Elansary, Afaf K. ^{[1
]}

Moneer, Ashraf A. ^{[1
]}

Kadry, Hanan H. ^{[1
]}

Gedawy, Ehab M. ^{[1
]}

机构：

[1] Cairo Univ, Fac Pharm, Dept Organ Pharmaceut Chem, Cairo 11562, Egypt

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2012年 / 35卷 / 11期

关键词：

Synthesis; Pyridothienopyrimidine; Thienodipyridine; Anticancer activity; INHIBITORS; POTENT; CYTOTOXICITY; AGENTS;

D O I：

10.1007/s12272-012-1107-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New series of pyrido[3',2':4,5]thieno[3,2-d]pyrimidines (7a,b) and thieno[2,3-b:4,5-b'] dipyridine (11a-c) were synthesized from 4-aryl-6-(4-chlorophenyl)-2-thioxo-1,2-dihydro pyridine-3-carbonitriles 4a,b via application of Thorpe-Zielger reaction. The novel target compounds were evaluated in vitro for their anticancer activity against human breast adenocarcinoma MCF-7 and colon carcinoma cell line (HCT 116). Most of the tested compounds exploited potent to moderate growth inhibitory activity, in particular compound 11d, which exhibited superior potency to the reference drug Doxorubicin (IC50 = 5.95, 6.09 and 8.48, 8.15 mu M, respectively). The structures of the compounds obtained were determined by spectroscopic data.

引用

页码：1909 / 1917

页数：9

共 50 条

[21] Synthesis, Characterization, and Anticancer Activity of Some Thiazole and Imidazolidine Derivatives Containing Pyridine Moiety
M. S. Al-Saleem
A. I. El-Shenawy
M. Abd El-Moneim
E. H. El-Sayed
Russian Journal of General Chemistry, 2018, 88 : 2675 - 2679
[22] Synthesis and Anticancer Activities of Novel Pyranocoumarin Fused Pyrimidine Based on Cyanoenamine
Huang, Xinwei
Liu, Jianli
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 38 (05) : 1233 - 1241
[23] Synthesis and anticancer activity evaluation of some novel imidazo[1,2-a]pyridine based heterocycles containing S-alkyl/aryl moiety
Kaya, Betul
Yurttas, Leyla
Baysal, Merve
Celikates, Buesra Korkut
Kaplancikli, Zafer Asim
Imamoglu, Rizvan
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2024, 199 (05) : 383 - 393
[24] Facile Synthesis and Anticancer Activity Study of Novel Series of Substituted and Fused Coumarin Derivatives
Hassan, A. Y.
Sarg, M. T.
El Deeb, M. A.
Bayoumi, A. H.
El Rabeb, S. I.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 55 (06) : 1426 - 1443
[25] Synthesis and anticancer activity of some novel trifluoromethylquinolines carrying a biologically active benzenesulfonamide moiety
Al-Dosari, Mohammed S.
Ghorab, Mostafa M.
Al Said, Mansour S.
Nissan, Yassin M.
Ahmed, Abdulkareem B.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 69 : 373 - 383
[26] Synthesis and Anticancer Activity of Novel Pyridine Derivatives Carrying a Biologically Active Benzenesulfonamide Moiety
Ghorab, Mostafa M.
Alsaid, Mansour S.
LATIN AMERICAN JOURNAL OF PHARMACY, 2016, 35 : 1102 - 1109
[27] Synthesis and Evaluation of Cytotoxic Activity of Some Pyrroles and Fused Pyrroles
Fatahala, Samar S.
Mohamed, Mosaad S.
Youns, Mahmoud
Abd-El Hameed, Rania H.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2017, 17 (07) : 1014 - 1025
[28] Synthesis and docking studies of novel benzopyran-2-ones with anticancer activity
Ismail, Magda M. F.
Rateb, Heba S.
Hussein, Mohammad M. M.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (09) : 3950 - 3959
[29] Synthesis and anticancer activity of novel 3,4-diarylthiazol-2(3H)-ones (imines)
Liu, Zong-Ying
Wang, Yue-Ming
Li, Zhuo-Rong
Jiang, Jian-Dong
Boykin, David W.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (19) : 5661 - 5664
[30] Synthesis and evaluation of some novel N-substituted rhodanines for their anticancer activity
Muhammad, Sulaiman Ali
Ravi, Subban
Thangamani, Arumugam
MEDICINAL CHEMISTRY RESEARCH, 2016, 25 (05) : 994 - 1004

← 1 2 3 4 5 →