Synthesis and anticancer activity of some novel fused pyridine ring system

被引：32

作者：

Elansary, Afaf K. ^{[1
]}

Moneer, Ashraf A. ^{[1
]}

Kadry, Hanan H. ^{[1
]}

Gedawy, Ehab M. ^{[1
]}

机构：

[1] Cairo Univ, Fac Pharm, Dept Organ Pharmaceut Chem, Cairo 11562, Egypt

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2012年 / 35卷 / 11期

关键词：

Synthesis; Pyridothienopyrimidine; Thienodipyridine; Anticancer activity; INHIBITORS; POTENT; CYTOTOXICITY; AGENTS;

D O I：

10.1007/s12272-012-1107-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New series of pyrido[3',2':4,5]thieno[3,2-d]pyrimidines (7a,b) and thieno[2,3-b:4,5-b'] dipyridine (11a-c) were synthesized from 4-aryl-6-(4-chlorophenyl)-2-thioxo-1,2-dihydro pyridine-3-carbonitriles 4a,b via application of Thorpe-Zielger reaction. The novel target compounds were evaluated in vitro for their anticancer activity against human breast adenocarcinoma MCF-7 and colon carcinoma cell line (HCT 116). Most of the tested compounds exploited potent to moderate growth inhibitory activity, in particular compound 11d, which exhibited superior potency to the reference drug Doxorubicin (IC50 = 5.95, 6.09 and 8.48, 8.15 mu M, respectively). The structures of the compounds obtained were determined by spectroscopic data.

引用

页码：1909 / 1917

页数：9

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