Cognitive Enhancing Effects of Alpha Asarone in Amnesic Mice by Influencing Cholinergic and Antioxidant Defense Mechanisms

被引：55
作者：
Kumar, Hemant [1 ]
Kim, Byung-Wook [1 ]
Song, Soo-Yeol [1 ]
Kim, Jun-Soo [1 ]
Kim, In-Su [1 ]
Kwon, Young-Sook [2 ]
Koppula, Sushruta [1 ]
Choi, Dong-Kug [1 ]
机构：
[1] Konkuk Univ, Dept Biotechnol, Chungju 380701, South Korea
[2] Joongbu Univ, Dept Nursing, Taejon 312702, South Korea
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2012年 / 76卷 / 08期
关键词：
alpha-asarone; acetylcholinesterase; passive avoidance; Y-maze; cognition; INDUCED MEMORY IMPAIRMENT; LONG-TERM POTENTIATION; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; RAT-BRAIN; MOUSE MODEL; SCOPOLAMINE; DEMENTIA; DEFICITS; EXTRACT;
D O I：
10.1271/bbb.120247
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of alpha-asarone on impairment of cognitive performance caused by amnesic drug scopolamine was investigated. Treatment with alpha-asarone attenuated scopolamine-induced cognitive deficits as evaluated by passive avoidance and Y-maze test. Administration of a-asarone for 15 d improved memory and cognitive function as indicated by an increase in transfer latency time and spontaneous alternation in passive avoidance and the Y-maze test respectively. To understand the action of alpha-asarone, the levels of acetylcholinesterase (AChE), malondialdehyde (MDA), and superoxide dismutase (SOD) in the hippocampus (Hippo) and cerebral cortex (CC) of scopolamine-induced amnesic mice were evaluated. The mice treated with Scopolamine showed increased activity of AChE, MDA and SOD levels in both the Hippo and the CC area. Treatment with alpha-asarone attenuated the increased activity of AChE and normalized the MDA and SOD levels in the Hippo and the CC area in the scopolamine treated amnesic mice. These results suggest that alpha-asarone has a beneficial effect in cognitive impairment induced by dysfunction of cholinergic system in brain through inhibition of AChE activity and by influencing the antioxidant defense mechanism.
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页码：1518 / 1522
页数：5
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