Predictive value of immunohistochemistry in pre-malignant lesions of the gastrointestinal tract

被引：6
作者：
Ma, Changqing [1 ]
Pai, Reetesh K. [1 ]
机构：
[1] Univ Pittsburgh, Presbyterian Hosp, Med Ctr, Dept Pathol, Pittsburgh, PA 15213 USA
来源：
SEMINARS IN DIAGNOSTIC PATHOLOGY | 2015年 / 32卷 / 05期
关键词：
Barrett's esophagus; Inflammatory bowel disease; Serrated polyps; Lynch syndrome; p53; PYLORIC GLAND ADENOMA; BRAF V600E MUTATION; DNA MISMATCH REPAIR; COENZYME-A RACEMASE; MICROSATELLITE INSTABILITY; BARRETTS METAPLASIA; ESOPHAGEAL ADENOCARCINOMA; NEOPLASTIC PROGRESSION; ULCERATIVE-COLITIS; PROTEIN EXPRESSION;
D O I：
10.1053/j.semdp.2015.02.014
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Immunohistochemistry can be an important adjunct to histopathology for the diagnosis of pre-malignant lesions of the gastrointestinal tract and in patient risk stratification. The purpose of this review is to provide information and guidance on the usefulness of immunohistochemical markers that facilitate the diagnosis of dysplasia and help to predict risk for the development of carcinoma in pre-malignant lesions of the gastrointestinal tract. Particular emphasis is given to the role of immunohistochemistry in the assessment of epithelial dysplasia in the setting of Barrett's esophagus and inflammatory bowel disease; supplementary immunohistochemistry for subtyping adenomas of the stomach and ampulla and serrated polyps of the colon and rectum; and ancillary markers of squamous neoplasia of the anal canal. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：334 / 343
页数：10
相关论文
共 59 条
  • [1] Gastric adenomas - Intestinal-type and gastric-type adenomas differ in the risk of adenocarcinorna and presence of background mucosal pathology
    Abraham, SC
    Montgomery, EA
    Singh, VK
    Yardley, JH
    Wu, TT
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2002, 26 (10) : 1276 - 1285
  • [2] Immunohistochemistry using the BRAF V600E mutation-specific monoclonal antibody VE1 is not a useful surrogate for genotyping in colorectal adenocarcinoma
    Adackapara, Cheryl A.
    Sholl, Lynette M.
    Barletta, Justine A.
    Hornick, Jason L.
    [J]. HISTOPATHOLOGY, 2013, 63 (02) : 187 - 193
  • [3] Ang DC, 2014, AM J SURG PATHOL, V38, P1371, DOI 10.1097/PAS.0000000000000230
  • [4] p16 Is Superior to ProEx C in Identifying High-grade Squamous Intraepithelial Lesions (HSIL) of the Anal Canal
    Bala, Rajeev
    Pinsky, Benjamin A.
    Beck, Andrew H.
    Kong, Christina S.
    Welton, Mark L.
    Longacre, Teri A.
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2013, 37 (05) : 659 - 668
  • [5] Bang YJ, 2010, LANCET, V376, P1302
  • [6] Expression of gastric pyloric mucin, MUC6, in colorectal serrated polyps
    Bartley, Angela N.
    Thompson, Patricia A.
    Buckmeier, Julie A.
    Kepler, Carole Y.
    Hsu, Chiu-Hsieh
    Snyder, Manuel S.
    Lance, Peter
    Bhattacharyya, Achyut
    Hamilton, Stanley R.
    [J]. MODERN PATHOLOGY, 2010, 23 (02) : 169 - 176
  • [7] Anal intraepithelial neoplasia:: Correlation of grade with p16INK4a lmmunohistochemistry and HPV in situ hybridization
    Bernard, Joan E.
    Butler, Mark O.
    Sandweiss, Lynn
    Weidner, Noel
    [J]. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2008, 16 (03) : 215 - 220
  • [8] Histomolecular Phenotypes and Outcome in Adenocarcinoma of the Ampulla of Vater
    Chang, David K.
    Jamieson, Nigel B.
    Johns, Amber L.
    Scarlett, Christopher J.
    Pajic, Marina
    Chou, Angela
    Pinese, Mark
    Humphris, Jeremy L.
    Jones, Marc D.
    Toon, Christopher
    Nagrial, Adnan M.
    Chantrill, Lorraine A.
    Chin, Venessa T.
    Pinho, Andreia V.
    Rooman, Ilse
    Cowley, Mark J.
    Wu, Jianmin
    Mead, R. Scott
    Colvin, Emily K.
    Samra, Jaswinder S.
    Corbo, Vincenzo
    Bassi, Claudio
    Falconi, Massimo
    Lawlor, Rita T.
    Crippa, Stefano
    Sperandio, Nicola
    Bersani, Samantha
    Dickson, Euan J.
    Mohamed, Mohamed A. A.
    Oien, Karin A.
    Foulis, Alan K.
    Musgrove, Elizabeth A.
    Sutherland, Robert L.
    Kench, James G.
    Carter, C. Ross
    Gill, Anthony J.
    Scarpa, Aldo
    McKay, Colin J.
    Biankin, Andrew V.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (10) : 1348 - 1356
  • [9] Pyloric Gland Adenoma An Entity Distinct From Gastric Foveolar Type Adenoma
    Chen, Zong-Ming
    Scudiere, Jennifer R.
    Abraham, Susan C.
    Montgomery, Elizabeth
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2009, 33 (02) : 186 - 193
  • [10] The Lower Anogenital Squamous Terminology Standardization Project for HPV-associated Lesions: Background and Consensus Recommendations From the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology
    Darragh, Teresa M.
    Colgan, Terence J.
    Cox, J. Thomas
    Heller, Debra S.
    Henry, Michael R.
    Luff, Ronald D.
    McCalmont, Timothy
    Nayar, Ritu
    Palefsky, Joel M.
    Stoler, Mark H.
    Wilkinson, Edward J.
    Zaino, Richard J.
    Wilbur, David C.
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2013, 32 (01) : 76 - 115
123456