Kidney transplantation and the ageing immune system

被引：43
作者：
McKay, Dianne [2 ]
Jameson, Julie [1 ]
机构：
[1] Calif State Univ San Marcos, Dept Biol, San Marcos, CA 92096 USA
[2] Univ Calif San Diego, Dept Med, Div Nephrol Hypertens, San Diego, CA 92161 USA
来源：
NATURE REVIEWS NEPHROLOGY | 2012年 / 8卷 / 12期
基金：
美国国家卫生研究院;
关键词：
AGE-ASSOCIATED DECLINE; HEMATOPOIETIC STEM-CELLS; PLASMACYTOID DENDRITIC CELLS; REGULATORY T-CELLS; RENAL-TRANSPLANTATION; HEART-TRANSPLANTATION; CLONAL EXPANSIONS; BONE-MARROW; NK CELLS; CYTOMEGALOVIRUS-INFECTION;
D O I：
10.1038/nrneph.2012.242
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The world population is rapidly growing and ageing at a pace that is projected to continue for at least three decades. This shift towards an older populace has invariably increased the number of individuals with diseases related to ageing, such as chronic kidney disease. The increase in chronic kidney disease is associated with a growing number of elderly patients receiving kidney transplants. Understanding how the immune system changes with increasing age will help to define the risks of rejection and infection in the elderly population and will focus attention on the need for individualized immunosuppression for patients in this age group. This Review addresses what is currently known about ageing and the immune system, highlighting age-related changes that affect the outcome of transplantation in elderly individuals. The need for new strategies to improve outcomes in this growing population of elderly renal transplant recipients is also emphasized.
引用
收藏
页码：700 / 708
页数：9
相关论文
共 122 条
  • [51] Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice
    Gorgas, G
    Butch, ER
    Guan, KL
    Miller, RA
    [J]. MECHANISMS OF AGEING AND DEVELOPMENT, 1997, 94 (1-3) : 71 - 83
  • [52] A proinflammatory state is associated with hyperhomocysteinemia in the elderly
    Gori, AM
    Corsi, AM
    Fedi, S
    Gazzini, A
    Sofi, F
    Bartali, B
    Bandinelli, S
    Gensini, GF
    Abbate, R
    Ferrucci, L
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2005, 82 (02) : 335 - 341
  • [53] PROGNOSTIC IMPORTANCE OF THE WHITE BLOOD-CELL COUNT FOR CORONARY, CANCER, AND ALL-CAUSE MORTALITY
    GRIMM, RH
    NEATON, JD
    LUDWIG, W
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1985, 254 (14): : 1932 - 1937
  • [54] Life and death of lymphocytes: A role in immunesenescence
    Gupta S.
    Su H.
    Bi R.
    Agrawal S.
    Gollapudi S.
    [J]. Immunity & Ageing, 2 (1)
  • [55] Interleukin 2, but not other common γ chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice
    Haynes, L
    Linton, PJ
    Eaton, SM
    Tonkonogy, SL
    Swain, SL
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (07) : 1013 - 1023
  • [56] IFN-γ-dependent transcription of MHC class IIIA is impaired in macrophages from aged mice
    Herrero, C
    Marqués, L
    Lloberas, J
    Celada, A
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (04) : 485 - 493
  • [57] Jacobsen P. A., AM J TRANSPLANT
  • [58] Johnson DW, 2000, TRANSPLANTATION, V69, P794
  • [59] Regulatory T Cells: Mechanisms of Differentiation and Function
    Josefowicz, Steven Z.
    Lu, Li-Fan
    Rudensky, Alexander Y.
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, VOL 30, 2012, 30 : 531 - 564
  • [60] Koch S, 2008, IMMUN AGEING, V5, DOI [10.1186/1742-4933-5-6, 10.1186/1742-4933-5-11]
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