Autism Spectrum Disorders in the Stockholm Youth Cohort: Design, Prevalence and Validity

被引:203
作者
Idring, Selma [1 ,2 ]
Rai, Dheeraj [1 ,3 ,4 ]
Dal, Henrik [1 ]
Dalman, Christina [1 ]
Sturm, Harald [2 ]
Zander, Eric [2 ,5 ,6 ]
Lee, Brian K. [7 ]
Serlachius, Eva [8 ]
Magnusson, Cecilia [1 ]
机构
[1] Karolinska Inst, Div Publ Hlth Epidemiol, Dept Publ Hlth Sci, Stockholm, Sweden
[2] Stockholm Cty Council, Neuropsychiat Resource Team SE Stockholm, Stockholm, Sweden
[3] Univ Bristol, Acad Unit Psychiat, Sch Social & Community Med, Bristol, Avon, England
[4] Avon & Wiltshire Partnership NHS Mental Hlth Trus, Bristol, Avon, England
[5] Karolinska Inst, Ctr Neurodev Disorders, Karolinska Inst KIND, Stockholm, Sweden
[6] Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden
[7] Drexel Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Philadelphia, PA 19104 USA
[8] Karolinska Inst, Div Psychiat, Dept Clin Neurosci, Stockholm, Sweden
来源
PLOS ONE | 2012年 / 7卷 / 07期
关键词
ENVIRONMENTAL-FACTORS; TELEPHONE INTERVIEW; CHILDHOOD AUTISM; A-TAC; CHILDREN; EPIDEMIOLOGY; ASSOCIATION; DIAGNOSIS; REGISTER; TICS;
D O I
10.1371/journal.pone.0041280
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Objective: Reports of rising prevalence of autism spectrum disorders (ASD), along with their profound personal and societal burden, emphasize the need of methodologically sound studies to explore their causes and consequences. We here present the design of a large intergenerational resource for ASD research, along with population-based prevalence estimates of ASD and their diagnostic validity. Method: The Stockholm Youth Cohort is a record-linkage study comprising all individuals aged 0-17 years, ever resident in Stockholm County in 2001-2007 (N = 589,114). ASD cases (N = 5,100) were identified using a multisource approach, involving registers covering all pathways to ASD diagnosis and care, and categorized according to co-morbid intellectual disability. Prospectively recorded information on potential determinants and consequences of ASD were retrieved from national and regional health and administrative registers. Case ascertainment was validated through case-note review, and cross validation with co-existing cases in a national twin study. Results: The 2007 year prevalence of ASD in all children and young people was 11.5 per 1,000 (95% confidence interval 11.2-11.8), with a co-morbid intellectual disability recorded in 42.6% (41.0-44.2) of cases. We found 96.0% (92.0-98.4) of reviewed case-notes being consistent with a diagnosis of ASD, and confirmed ASD in 85.2% (66.2-95.8) of affected twins. Conclusions: Findings from this contemporary study accords with recently reported prevalence estimates from Western countries at around 1%, based on valid case ascertainment. The Stockholm Youth Cohort, in light of the availability of extensive information from Sweden's registers, constitutes an important resource for ASD research. On-going work, including collection of biological samples, will enrich the study further.
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页数:9
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