Minocycline up-regulates the expression of brain-derived neurotrophic factor and nerve growth factor in experimental autoimmune encephalomyelitis

被引：19

作者：

Chen, Xiaohong ^{[1
]}

Ma, Lili ^{[1
]}

Jiang, Ying ^{[1
]}

Chen, Shaoqiong ^{[2
]}

Zhu, Cansheng ^{[1
]}

Liu, Mei ^{[1
]}

Ma, Xiaomeng ^{[1
]}

Zhu, Dongliang ^{[1
]}

Liu, Yingying ^{[1
]}

Peng, Fuhua ^{[1
]}

Wang, Qing ^{[1
]}

Pi, Rongbiao ^{[3
]}

机构：

[1] Sun Yat Sen Univ, Dept Neurol, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Dept Radiol, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Dept Pharmacol & Toxicol, Sch Pharmaceut Sci, Guangzhou 510630, Guangdong, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2012年 / 686卷 / 1-3期

基金：

中国国家自然科学基金;

关键词：

Minocycline; Experimental autoimmune encephalomyelitis; Brain-derived neurotrophic factor; Nerve growth factor; Multiple sclerosis; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MULTIPLE-SCLEROSIS; SPINAL-CORD; T-CELLS; NEUROPROTECTION; EAE; SECRETION; NEURONS; INFLAMMATION; PROSPECTS;

D O I：

10.1016/j.ejphar.2012.04.043

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Previous evidence demonstrated that minocycline could ameliorate clinical severity of experimental autoimmune encephalomyelitis and exhibit several anti-inflammatory and neuroprotective activities. However, few studies have been carried out to assess its effects on the expression of neurotrophins in experimental autoimmune encephalomyelitis or multiple sclerosis. Here we investigated the alteration of brain-derived neurotrophic factor and nerve growth factor in the sera, cerebral cortex, and lumbar spinal cord of experimental autoimmune encephalomyelitis C57 BL/6 mice in vivo as well as the splenocytes culture supernatants in vitro after minocycline administration. Our results demonstrated that minocycline could up-regulate the expression of brain-derived neurotrophic factor and nerve growth factor both in peripheral (sera and splenocytes culture supernatants) and target organs (cerebral cortex and lumber spinal cord) of mice with experimental autoimmune encephalomyelitis. These data suggest that up-regulation of neurotrophins in experimental autoimmune encephalomyelitis may be a novel neuroprotective mechanism of minocycline. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：124 / 129

页数：6

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