The association between HDAC9 gene polymorphisms and stroke risk in the Chinese population: A meta-analysis

被引:12
|
作者
Zhou, Xin [1 ]
Guan, Tangming [2 ]
Li, Shuyuan [1 ]
Jiao, Zinan [1 ]
Lu, Xiaoshuang [1 ]
Huang, Xiaodi [1 ]
Ji, Yuhua [1 ]
Ji, Qiuhong [3 ]
机构
[1] Jinan Univ, Coll Life Sci & Technol, Inst Immunol, Guangzhou 510630, Guangdong, Peoples R China
[2] Guangdong Med Univ, Affiliated Hosp, Zhanjiang 524001, Peoples R China
[3] Nantong Univ, Affiliated Hosp, Dept Neurol, Nantong 226002, Peoples R China
来源
SCIENTIFIC REPORTS | 2017年 / 7卷
关键词
ISCHEMIC-STROKE; ATHEROSCLEROSIS; DISEASE;
D O I
10.1038/srep41538
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Several recent genome-wide association studies (GWASs) have suggested that the histone deacetylase 9 (HDAC9) gene is associated with stroke, but the reliability of these findings remains controversial, particularly for the data derived from different ethnicities and geographical locations. Therefore, we performed a meta-analysis to explore the associations between HDAC9 polymorphisms and the risk of stroke in the Chinese population. All eligible case-control studies that met the search criteria were retrieved from multiple databases, and six case-control studies with a total of 2,356 stroke patients and 3,420 healthy controls were included. The pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to assess the strengths of the associations of 3 HDAC9 gene polymorphisms with stroke risk. Our results revealed statistically significant associations of the rs2107595 (T/C) polymorphism with an increased risk of stroke in the allele, codominant and dominant models. Additionally, the rs2389995 (G/A) polymorphism was found to be significantly associated with a decreased risk of stroke in all genetic models. In conclusion, this meta-analysis suggested that the T allele of rs2107595 in HDAC9 increases the risk of stroke but that the G allele of rs2389995 decreases the risk of stroke in the Chinese population.
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页数:11
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