A translational medicine appraisal of specialized andrology testing in unexplained male infertility

被引：75

作者：

Esteves, Sandro C. ^{[1
]}

Sharma, Rakesh K. ^{[2
]}

Gosalvez, Jaime ^{[3
]}

Agarwal, Ashok ^{[2
]}

机构：

[1] Androfert, Androl & Human Reprod Clin, BR-13075460 Sao Paulo, Brazil

[2] Cleveland Clin, Ctr Reprod Med, Cleveland, OH 44106 USA

[3] Univ Autonoma Madrid, Genet Unit, Dept Biol, Madrid, Spain

来源：

INTERNATIONAL UROLOGY AND NEPHROLOGY | 2014年 / 46卷 / 06期

关键词：

Andrology; Male infertility; Diagnostic techniques and procedures; Translational medical research; Review; CHROMATIN-STRUCTURE ASSAY; SPERM DNA FRAGMENTATION; DEOXYRIBONUCLEIC-ACID FRAGMENTATION; IN-VITRO FERTILIZATION; TOTAL ANTIOXIDANT CAPACITY; ZONA-PELLUCIDA; INTRAUTERINE INSEMINATION; PROTEOMIC ANALYSIS; HUMAN SPERMATOZOA; OXIDATIVE STRESS;

D O I：

10.1007/s11255-014-0715-0

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The diagnostic and prognostic validity of sperm function biomarkers is particularly relevant for males with unexplained infertility in which routine semen analysis fails to detect subcellular sperm dysfunctions. In this general review, we examine the role and significance of specialized andrology laboratory tests from past to present and provide a glance toward the future. We concluded that the assessment of sperm DNA damage and oxidative stress provide a relatively independent measure of fertility that yields diagnostic and prognostic information complementary to, but distinct and more significant than, standard sperm parameters. Since none of the available methods for such testing have been fully translated, further research is necessary to evaluate their cost-effectiveness when applied in large scale to daily medical practice. Application of translational medicine concepts would also be useful to accelerate the clinical application of recent discoveries in the fields of genomics, proteomics and metabolomics.

引用

页码：1037 / 1052

页数：16

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