Functional differentiation and regulation of follicular T helper cells in inflammation and autoimmunity

被引：28

作者：

Dong, Lin ^{[1
]}

He, Ying ^{[1
]}

Cao, Yejin ^{[1
]}

Wang, Yuexin ^{[1
]}

Jia, Anna ^{[1
]}

Wang, Yufei ^{[1
]}

Yang, Qiuli ^{[1
]}

Li, Wanjie ^{[1
]}

Bi, Yujing ^{[2
]}

Liu, Guangwei ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Life Sci, Key Lab Cell Proliferat & Regulat Biol, Minist Educ,Inst Cell Biol, Beijing, Peoples R China

[2] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China

来源：

IMMUNOLOGY | 2021年 / 163卷 / 01期

关键词：

follicular T helper cells; metabolic reprogramming; signalling; infectious diseases; cancer; inflammation; SUPPRESSOR-CELLS; BCL6; EXPRESSION; FH CELLS; C-MAF; AXIS; PROMOTES; MEMORY; PHENOTYPE; IMMUNITY; SUBSET;

D O I：

10.1111/imm.13282

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Follicular T helper (T-FH) cells are specialized T cells that support B cells, which are essential for humoral immunity. T-FH cells express the transcription factor B-cell lymphoma 6 (Bcl-6), chemokine (C-X-C motif) receptor (CXCR) 5, the surface receptors programmed cell death protein 1 (PD-1) and inducible T-cell costimulator (ICOS), the cytokine IL-21 and other molecules. The activation, proliferation and differentiation of T-FH cells are closely related to dynamic changes in cellular metabolism. In this review, we summarize the progress made in understanding the development and functional differentiation of T-FH cells. Specifically, we focus on the regulatory mechanisms of T-FH cell functional differentiation, including regulatory signalling pathways and the metabolic regulatory mechanisms of T-FH cells. In addition, T-FH cells are closely related to immune-associated diseases, including infections, autoimmune diseases and cancers.

引用

页码：19 / 32

页数：14

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