Studies on pyrrolidinones:: Some attempts to improve the synthesis of methyl N-(3,4,4′,5-tetramethoxybenzhydryl)pyroglutamate (HEI 81) by using N-acyl iminium salts methodologies.

被引：6
作者：
Bourry, A
Pitard, F
Rigo, B
Sanz, G
Camus, F
Norberg, B
Durant, F
Couturier, D
机构：
[1] Ecole Hautes Etud Ind, Grp Rech Inhibit Proliferat Cellulaire, F-59046 Lille, France
[2] Janssen Res Fdn, F-27106 Val De Reuil, France
[3] Fac Univ Notre Dame Paix, Lab Chim Mol Struct, B-5000 Namur, Belgium
[4] Univ Sci & Technol, Lab Ingn Mol, F-59655 Villeneuve Dascq, France
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2002年 / 39卷 / 01期
关键词：
D O I：
10.1002/jhet.5570390116
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Some ways to use the N-acyl iminium salt methodologies to synthesize a new inhibitor of tubulin polymerization, methyl N-(3,4,4',5-tetramethoxybenzhydryl)pyroglutamate (HEI 81) were studied. The most interesting reactions utilize a new pyroglutamic lactone (3-(3,4,5-trimethoxyphenyl)dihydropyrrolo[1,2-c]oxazole-1,5-dione).
引用
收藏
页码：109 / 118
页数：10
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