Kinetics of Schiff base formation between the cholesterol ozonolysis product 3β-hydroxy-5-oxo-5,6-secocholestan-6-al and phosphatidylethanolamine

被引：12

作者：

Bach, D. ^{[1
]}

Wachtel, E. ^{[2
]}

Miller, I. R. ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

[2] Weizmann Inst Sci, Fac Chem, Chem Res Infrastruct Unit, IL-76100 Rehovot, Israel

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2009年 / 157卷 / 01期

关键词：

Phospholipids; Oxidized cholesterol; Schiff base; OZONATION PRODUCT; APOPTOSIS;

D O I：

10.1016/j.chemphyslip.2008.09.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The kinetics of Schiff base formation between the cholesterol ozonolysis product 3 beta-hydroxy-5-oxo-5,6-secocholestan-6-al and dimyristoyl phosphatidylethanolamine was investigated. The activation energy of Schiff base formation at temperatures above and below the phase transition of the phospholipid was calculated. Increase in the activation energy derived from perturbation of the surface structure by the process of Schiff base formation was demonstrated. The presence of the Schiff base with the aldolization product of the oxysterol was also observed and its significance is discussed. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：51 / 55

页数：5

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