DNA Demethylation in Pluripotency and Reprogramming: The Role of Tet Proteins and Cell Division

被引：57

作者：

Bagci, Hakan ^{[1
]}

Fisher, Amanda G. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, MRC Clin Sci Ctr, Lymphocyte Dev Grp, London W12 0NN, England

来源：

CELL STEM CELL | 2013年 / 13卷 / 03期

基金：

英国医学研究理事会;

关键词：

EMBRYONIC STEM-CELLS; PRIMORDIAL GERM-CELLS; PREIMPLANTATION DEVELOPMENT; SELF-RENEWAL; METHYLATION; ERASURE; GENOME; 5-HYDROXYMETHYLCYTOSINE; REPLICATION; GENERATION;

D O I：

10.1016/j.stem.2013.08.005

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Cytosine methylation is found in the genomes of many plants and animals and has been associated with transcriptional silencing in mammals. At critical stages in embryo development, when cellular potential is reset, DNA methylation is lost in a series of "sequential waves." The mechanism underlying this is controversial and complex. Several new reports now suggest that TET enzymes and cell division are important for these in vivo transitions as well as for experimentally induced reprogramming.

引用

页码：265 / 269

页数：5

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