STAT3 promotes corticospinal remodelling and functional recovery after spinal cord injury

被引：75

作者：

Lang, Claudia ^{[1
]}

Bradley, Peter M. ^{[1
]}

Jacobi, Anne ^{[1
]}

Kerschensteiner, Martin ^{[1
,2
]}

Bareyre, Florence M. ^{[1
,2
]}

机构：

[1] Univ Munich, Inst Clin Neuroimmunol, D-81377 Munich, Germany

[2] Munich Cluster Syst Neurol SyNergy, Munich, Germany

来源：

EMBO REPORTS | 2013年 / 14卷 / 10期

基金：

欧洲研究理事会;

关键词：

axonal remodelling; corticospinal tract; neuronal plasticity; spinal cord injury; STAT3; AXONAL PLASTICITY;

D O I：

10.1038/embor.2013.117

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

If and how neurons remodel their connections after CNS injury critically influences recovery of function. Here, we investigate the role of the growth-initiating transcription factor STAT3 during remodelling of the injured corticospinal tract (CST). Endogenous STAT3 expression in lesioned cortical projection neurons is transient but can be sustained by viral gene transfer. Sustained activation of STAT3 enhances remodelling of lesioned CST fibres and induces de novo formation of collaterals from unlesioned CST fibres. In a unilateral pyramidotomy paradigm, this recruitment of unlesioned fibres leads to the formation of midline crossing circuits that establish ipsilateral forelimb activation and functional recovery.

引用

页码：931 / 937

页数：7

共 20 条

[1] In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration [J].

Bareyre, Florence M. ;

Garzorz, Natalie ;

Lang, Claudia ;

Misgeld, Thomas ;

Buening, Hildegard ;

Kerschensteiner, Martin .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (15) :6282-6287

[2] The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats [J].

Bareyre, FM ;

Kerschensteiner, M ;

Raineteau, O ;

Mettenleiter, TC ;

Weinmann, O ;

Schwab, ME .

NATURE NEUROSCIENCE, 2004, 7 (03) :269-277

[3] Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury [J].

Courtine, Gregoire ;

Song, Bingbing ;

Roy, Roland R. ;

Zhong, Hui ;

Herrmann, Julia E. ;

Ao, Yan ;

Qi, Jingwei ;

Edgerton, V. Reggie ;

Sofroniew, Michael V. .

NATURE MEDICINE, 2008, 14 (01) :69-74

[4] Locomotor capacity and recovery of spinal cord function in paraplegic patients: a clinical and electrophysiological evaluation [J].

Dietz, V ;

Wirz, M ;

Colombo, G ;

Curt, A .

ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1998, 109 (02) :140-153

[5] Cervical sprouting of corticospinal fibers after thoracic spinal cord injury accompanies shifts in evoked motor responses [J].

Fouad, K ;

Pedersen, V ;

Schwab, ME ;

Brösamle, C .

CURRENT BIOLOGY, 2001, 11 (22) :1766-1770

[6] Reaching training in rats with spinal cord injury promotes plasticity and task specific recovery [J].

Girgis, J. ;

Merrett, D. ;

Kirkland, S. ;

Metz, G. A. S. ;

Verge, V. ;

Fouad, K. .

BRAIN, 2007, 130 :2993-3003

[7]

Gorski JA, 2002, J NEUROSCI, V22, P6309

[8] Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study [J].

Harkema, Susan ;

Gerasimenko, Yury ;

Hodes, Jonathan ;

Burdick, Joel ;

Angeli, Claudia ;

Chen, Yangsheng ;

Ferreira, Christie ;

Willhite, Andrea ;

Rejc, Enrico ;

Grossman, Robert G. ;

Edgerton, V. Reggie .

LANCET, 2011, 377 (9781) :1938-1947

[9] Single Collateral Reconstructions Reveal Distinct Phases of Corticospinal Remodeling after Spinal Cord Injury [J].

Lang, Claudia ;

Guo, Xiaoli ;

Kerschensteiner, Martin ;

Bareyre, Florence M. .

PLOS ONE, 2012, 7 (01)

[10] Neuronal Intrinsic Mechanisms of Axon Regeneration [J].

Liu, Kai ;

Tedeschi, Andrea ;

Park, Kevin Kyungsuk ;

He, Zhigang .

ANNUAL REVIEW OF NEUROSCIENCE, VOL 34, 2011, 34 :131-152

← 1 2 →