Enhancement of the serotonin-mediated acetylcholine release by repeated desmethylimipramine treatment in the hippocampus of freely moving rats

被引：6
作者：
Fujii, T [1 ]
Ohba, S [1 ]
Nakai, K [1 ]
Fujimoto, K [1 ]
Suzuki, T [1 ]
Kawashima, K [1 ]
机构：
[1] Kyoritsu Coll Pharm, Dept Pharmacol, Minato Ku, Tokyo 1058512, Japan
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1999年 / 80卷 / 04期
关键词：
acetylcholine; desmethylimipramine; hippocampus; microdialysis; serotonin (5-HT);
D O I：
10.1254/jjp.80.303
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A possible involvement of serotonin-mediated cholinergic activation in the antidepressant effect of desmethylimipramine (DMI) was investigated by determination of the effects of a single or repeated DMI administration on acetylcholine (ACh) release in the hippocampus using an in vivo microdialysis technique and a radioimmunoassay for ACh. Rats were administered DMI (10 mg/kg, i.p.) acutely or repeatedly for 21 days. A single or repeated DMI administration did not cause any significant effects on the basal ACh release compared with the respective controls. Atropine perfusion in the acutely DMI-treated or control rats increased the ACh release to the same degree. In repeatedly DMI-treated rats, serotonin (5-HT) (1 to 10 mu M) perfusion enhanced significantly the ACh release. However, 5-HT in acutely DMI-treated rats enhanced significantly the ACh release only at 10 mu M. 5-HT did not cause any changes in ACh release in control rats. Hippocampal 5-HT content of acutely DMI-treated rats was significantly higher than that of saline-treated control rats, while no difference was observed between the repeatedly DMI- and saline-treated rats. These findings suggest, for the first time, that DMI induced a facilitation of cholinergic neurotransmission in the rat hippocampus through the activation of 5-HT-receptor function.
引用
收藏
页码：303 / 309
页数：7
相关论文
共 50 条
[31]   EFFECTS OF THE CENTRALLY ACTING CHOLINESTERASE-INHIBITORS TETRAHYDROAMINOACRIDINE AND E2020 ON THE BASAL CONCENTRATION OF EXTRACELLULAR ACETYLCHOLINE IN THE HIPPOCAMPUS OF FREELY MOVING RATS [J].
KAWASHIMA, K ;
SATO, A ;
YOSHIZAWA, M ;
FUJII, T ;
FUJIMOTO, K ;
SUZUKI, T .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1994, 350 (05) :523-528
[32]   The neurosteroid pregnenolone sulfate increases cortical acetylcholine release:: A microdialysis study in freely moving rats [J].
Darnaudéry, M ;
Koehl, M ;
Pallarés, M ;
Le Moal, M ;
Mayo, W .
JOURNAL OF NEUROCHEMISTRY, 1998, 71 (05) :2018-2022
[33]   MODULATION OF HIPPOCAMPAL ACH RELEASE BY CHRONIC NICERGOLINE TREATMENT IN FREELY MOVING YOUNG AND AGED RATS [J].
CARFAGNA, N ;
DICLEMENTE, A ;
CAVANUS, S ;
DAMIANI, D ;
GERNA, M ;
SALMOIRAGHI, P ;
CATTANEO, B ;
POST, C .
NEUROSCIENCE LETTERS, 1995, 197 (03) :195-198
[34]   Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats [J].
Hatip-Al-Khatib, I ;
Iwasaki, K ;
Yoshimitsu, Y ;
Arai, T ;
Egashira, N ;
Mishima, K ;
Ikeda, T ;
Fujiwara, M .
BRITISH JOURNAL OF PHARMACOLOGY, 2005, 145 (08) :1035-1044
[35]   Effects of acute and chronic lamotrigine treatment on basal and stimulated extracellular amino acids in the hippocampus of freely moving rats [J].
Ahmad, S ;
Fowler, LJ ;
Whitton, PS .
BRAIN RESEARCH, 2004, 1029 (01) :41-47
[36]   Increase of acetylcholine release from cortex of freely moving rats by administration of histamine into the nucleus basalis magnocellularis [J].
M. Cecchi ;
M. Giorgetti ;
L. Bacciottini ;
M. G. Giovannini ;
P. Blandina .
Inflammation Research, 1998, 47 (Suppl 1) :32-33
[37]   Inhibition by the neurosteroid allopregnanolone of basal and stress-induced acetylcholine release in the brain of freely moving rats [J].
Dazzi, L ;
Sanna, A ;
Cagetti, E ;
Concas, A ;
Biggio, G .
BRAIN RESEARCH, 1996, 710 (1-2) :275-280
[38]   EFFECT OF ACUTE ADMINISTRATION OF NICOTINE ON INVIVO RELEASE OF NORADRENALINE IN THE HIPPOCAMPUS OF FREELY MOVING RATS - A DOSE-RESPONSE AND ANTAGONIST STUDY [J].
BRAZELL, MP ;
MITCHELL, SN ;
GRAY, JA .
NEUROPHARMACOLOGY, 1991, 30 (08) :823-833
[39]   Tramadol increases extracellular levels of serotonin and noradrenaline as measured by in vivo microdialysis in the ventral hippocampus of freely-moving rats [J].
Bloms-Funke, P. ;
Dremencov, E. ;
Cremers, T. I. F. H. ;
Tzschentke, T. M. .
NEUROSCIENCE LETTERS, 2011, 490 (03) :191-195
[40]   Acetylcholine release, EEG spectral analysis, sleep staging and body temperature studies: A multiparametric approach on freely moving rats [J].
Crouzier, D ;
Baubichon, D ;
Bourbon, F ;
Testylier, G .
JOURNAL OF NEUROSCIENCE METHODS, 2006, 151 (02) :159-167
12345