[1] Univ Aveiro, Ctr Environm & Marine Studies CESAM, P-3810193 Aveiro, Portugal
[2] Univ Aveiro, Ctr Mech Technol & Automat TEMA, P-3810193 Aveiro, Portugal
[3] Univ Aveiro, Dept Mech Engn, P-3810193 Aveiro, Portugal
[4] Univ Toledo, Coll Pharm & Pharmaceut Sci, Dept Med & Biol Chem, Toledo, OH 43606 USA
[5] Univ Aveiro, Dept Biol, P-3810193 Aveiro, Portugal