Roles of miR-17-92 Cluster in Cardiovascular Development and Common Diseases

被引：34
|
作者：
Gu, Huanyu [1 ]
Liu, Zhuyuan [1 ]
Zhou, Lei [1 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing 210029, Jiangsu, Peoples R China
来源：
BIOMED RESEARCH INTERNATIONAL | 2017年 / 2017卷
基金：
中国国家自然科学基金;
关键词：
KEY ONCOGENIC COMPONENT; PROLIFERATION; DIFFERENTIATION; EXPRESSION; MICRORNAS; FAMILY; OVEREXPRESSION; DYSREGULATION; INHIBITION; MORTALITY;
D O I：
10.1155/2017/9102909
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
MicroRNAs (miRNAs and miRs) are a large class of noncoding, single-stranded, small RNA molecules. The precise control of their expression is essential for keeping tissue homeostasis and normal development of organisms. Thus, unbalanced expression of miRNAs is a hallmark of many diseases. Two to dozens of miRNAs can forminto a miRNA cluster, and the miR-17-92 cluster is one of them. Although firstly described as an oncogenic miRNA cluster, the miR-17-92 cluster has also been found to play critical role in normal cardiac development and cardiovascular disease. This review focuses on the characteristics and functions of miR-17-92 cluster in heart.
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页数：6
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