Auditory Closed-Loop Stimulation of the Sleep Slow Oscillation Enhances Memory

被引：580

作者：

Ngo, Hong-Viet V. ^{[1
,2
,3
,4
]}

Martinetz, Thomas ^{[3
]}

Born, Jan ^{[1
,2
,5
]}

Moelle, Matthias ^{[1
,2
,5
]}

机构：

[1] Univ Tubingen, Inst Med Psychol & Behav Neurobiol, D-72076 Tubingen, Germany

[2] Univ Tubingen, Ctr Integrat Neurosci, D-72076 Tubingen, Germany

[3] Med Univ Lubeck, Inst Neuro & Bioinformat, D-23538 Lubeck, Germany

[4] Med Univ Lubeck, Grad Sch Comp Med & Life Sci, D-23538 Lubeck, Germany

[5] Med Univ Lubeck, Dept Neuroendocrinol, D-23538 Lubeck, Germany

来源：

NEURON | 2013年 / 78卷 / 03期

关键词：

TRANSCRANIAL MAGNETIC STIMULATION; K-COMPLEX REPRESENTS; CORTICAL DOWN-STATE; EYE-MOVEMENT SLEEP; ELECTRICAL-STIMULATION; NEURONAL PLASTICITY; SPINDLES; WAVES; CONSOLIDATION; EEG;

D O I：

10.1016/j.neuron.2013.03.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain rhythms regulate information processing in different states to enable learning and memory formation. The <1 Hz sleep slow oscillation hallmarks slow-wave sleep and is critical to memory consolidation. Here we show in sleeping humans that auditory stimulation in phase with the ongoing rhythmic occurrence of slow oscillation up states profoundly enhances the slow oscillation rhythm, phase-coupled spindle activity, and, consequently, the consolidation of declarative memory. Stimulation out of phase with the ongoing slow oscillation rhythm remained ineffective. Closed-loop in-phase stimulation provides a straight-forward tool to enhance sleep rhythms and their functional efficacy.

引用

页码：545 / 553

页数：9

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