Dendritic cell-based cancer immunotherapy for pancreatic cancer

被引：15

作者：

Li, Wei ^{[1
]}

Song, Xiujun ^{[1
]}

Yu, Huijie ^{[1
]}

Zhang, Manze ^{[1
]}

Li, Fengsheng ^{[1
]}

Cao, Cheng ^{[2
]}

Jiang, Qisheng ^{[1
]}

机构：

[1] PLA Rocket Force, Gen Hosp, Lab Nucl & Radiat Damage, Beijing 100088, Peoples R China

[2] Beijing Inst Biotechnol, Beijing 100850, Peoples R China

来源：

ARAB JOURNAL OF GASTROENTEROLOGY | 2018年 / 19卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Pancreatic cancer; Immunotherapy; Dendritic cells; ANTITUMOR IMMUNITY; T-CELL; TUMOR-LYSATE; IN-VIVO; DUCTAL ADENOCARCINOMA; CLINICAL-SIGNIFICANCE; COMBINATION THERAPY; CARCINOMA PATIENTS; MESSENGER-RNA; GEMCITABINE;

D O I：

10.1016/j.ajg.2017.05.013

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pancreatic cancer (PC) is a lethal disease and remains one of the most resistant cancers to traditional therapies. New therapeutic modalities are urgently needed, particularly immunotherapy, which has shown promise in numerous animal model studies. Dendritic cell (DC)-based immunotherapy has been used in clinical trials for various cancers, including PC, because DCs are the most potent antigen-presenting cell (APC), which are capable of priming naive T cells and stimulating memory T cells to generate antigen-specific responses. In this paper, we review the preclinical and clinical efforts towards the application of DCs for PC. (C) 2017 Published by Elsevier B. V. on behalf of Pan-Arab Association of Gastroenterology.

引用

页码：1 / 6

页数：6

共 99 条

[1] Current Experience With CTLA4-blocking Monoclonal Antibodies for the Treatment of Solid Tumors [J].

Agarwala, Sanjiv S. ;

Ribas, Antoni .

JOURNAL OF IMMUNOTHERAPY, 2010, 33 (06) :557-569

[2] Antitumor effects induced by dendritic cell-based immunotherapy against established pancreatic cancer in hamsters [J].

Akiyama, Y ;

Maruyama, K ;

Nara, N ;

Hojo, T ;

Cheng, JY ;

Mori, T ;

Wiltrout, RH ;

Yamaguchi, K .

CANCER LETTERS, 2002, 184 (01) :37-47

[3] Cross-talk between dendritic cells and natural killer cells in viral infection [J].

Andrews, DM ;

Andoniou, CE ;

Scalzo, AA ;

van Dommelen, SLH ;

Wallace, ME ;

Smyth, MJ ;

Degli-Esposti, MA .

MOLECULAR IMMUNOLOGY, 2005, 42 (04) :547-555

[4] Immunobiology of dendritic cells [J].

Banchereau, J ;

Briere, F ;

Caux, C ;

Davoust, J ;

Lebecque, S ;

Liu, YT ;

Pulendran, B ;

Palucka, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+

[5] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[6] Dendritic cell-based vaccination combined with gemcitabine increases survival in a murine pancreatic carcinoma model [J].

Bauer, C. ;

Bauernfeind, F. ;

Sterzik, A. ;

Orban, M. ;

Schnurr, M. ;

Lehr, H. A. ;

Endres, S. ;

Eigler, A. ;

Dauer, M. .

GUT, 2007, 56 (09) :1275-1282

[7] Concomitant gemcitabine therapy negatively affects DC vaccine-induced CD8+ T-cell and B-cell responses but improves clinical efficacy in a murine pancreatic carcinoma model [J].

Bauer, Christian ;

Sterzik, Alexander ;

Bauernfeind, Franz ;

Duewell, Peter ;

Conrad, Claudius ;

Kiefl, Rosemarie ;

Endres, Stefan ;

Eigler, Andreas ;

Schnurr, Max ;

Dauer, Marc .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2014, 63 (04) :321-333

[8] Tumor-associated transforming growth factor-β and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients [J].

Bellone, G ;

Turletti, A ;

Artusio, E ;

Mareschi, K ;

Carbone, A ;

Tibaudi, D ;

Robecchi, A ;

Emanuelli, G ;

Rodeck, U .

AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (02) :537-547

[9] Design and development of synthetic peptide vaccines: past, present and future [J].

Bijker, Martijn S. ;

Melief, Cornelis Jm ;

Offringa, Rienk ;

van der Burg, Sjoerd H. .

EXPERT REVIEW OF VACCINES, 2007, 6 (04) :591-603

[10] Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer [J].

Brahmer, Julie R. ;

Tykodi, Scott S. ;

Chow, Laura Q. M. ;

Hwu, Wen-Jen ;

Topalian, Suzanne L. ;

Hwu, Patrick ;

Drake, Charles G. ;

Camacho, Luis H. ;

Kauh, John ;

Odunsi, Kunle ;

Pitot, Henry C. ;

Hamid, Omid ;

Bhatia, Shailender ;

Martins, Renato ;

Eaton, Keith ;

Chen, Shuming ;

Salay, Theresa M. ;

Alaparthy, Suresh ;

Grosso, Joseph F. ;

Korman, Alan J. ;

Parker, Susan M. ;

Agrawal, Shruti ;

Goldberg, Stacie M. ;

Pardoll, Drew M. ;

Gupta, Ashok ;

Wigginton, Jon M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (26) :2455-2465

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