Antinociceptive effects of lead acetate in sciatic nerve chronic constriction injury model of peripheral neuropathy in maleWistarrats

被引：1

作者：

Owoyele, Bamidele Victor ^{[1
]}

Bakare, Ahmed Olalekan ^{[1
]}

Ayinla, Maryam Tayo ^{[1
]}

Adeshina, Kehinde Ahmed ^{[1
]}

Onietan, Damilola ^{[1
]}

Azeez, Saheed O. ^{[1
]}

机构：

[1] Univ Ilorin, Fac Basic Med Sci, Dept Physiol, Neurosci & Inflammat Unit, Ilorin, Kwara State, Nigeria

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2021年 / 394卷 / 01期

关键词：

Allodynia; Hyperalgesia; Lead acetate; Memory; Neuropathic pain; Sciatic nerve; SPINAL DORSAL-HORN; PKM-ZETA; PAIN; MICE; NEUROTOXICITY; MECHANISMS; EXPOSURE; RATS;

D O I：

10.1007/s00210-020-01951-w

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The toxicological effects of lead and its compounds have overshadowed its possible health beneficial effects. Currently, the success rate for treating neuropathic pain has been very low. This study investigated the antinociceptive effects of orally administered low dose lead acetate in sciatic nerve ligatedWistarrats. ThirtyWistarrats randomly divided into five groups were used for this study. Chronic constriction injury (CCI) was used to induce neuropathic pain inWistarrats. Allodynic and hyperalgesic signs were investigated using von Frey filaments and hotplate, respectively. Morris water maze test was used to assess the memory functions of the rats. The study revealed that oral administration of low-dose lead acetate significantly (p < 0.05) increased pain thresholds of ligated rats. CCI enhanced memory function inWistarrats which was significantly decreased following lead acetate administration. The findings suggest that lead acetate possesses antinociceptive effects in peripherally induced neuropathic pain model in Wistar rats.

引用

页码：117 / 125

页数：9

共 39 条

[1] Protective Role of Omega-3 Polyunsaturated Fatty Acid against Lead Acetate-Induced Toxicity in Liver and Kidney of Female Rats [J].