Biomechanics of Intervertebral Disk Degeneration

被引:171
作者
Inoue, Nozomu [1 ]
Orias, Alejandro A. Espinoza [1 ]
机构
[1] Rush Univ, Spine Biomech Lab, Dept Orthoped Surg, Med Ctr, Chicago, IL 60612 USA
关键词
Biomechanics; Intervertebral disk; Degeneration; LOW-BACK-PAIN; LUMBAR ANULUS FIBROSUS; PULPOSUS GLYCOSAMINOGLYCAN CONTENT; PRIZE WINNER MICROSTRUCTURE; SPINAL MOTION SEGMENTS; IN-VIVO MEASUREMENTS; X-RAY-ANALYSIS; FLEXION-EXTENSION; NUCLEUS PULPOSUS; INTRADISCAL PRESSURE;
D O I
10.1016/j.ocl.2011.07.001
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Degenerative changes in the material properties of nucleus pulposus and nulus fibrosus promote changes in viscoelastic properties of the whole disk. Volume, pressure and hydration loss in the nucleus pulposus, disk height decreases and fissures in the anulus fibrosus, are some of the signs of the degenerative cascade that advances with age and affect, among others, spinal function and its stability. Much remains to be learned about how these changes affect the function of the motion segment and relate to symptoms such as low back pain and altered spinal biomechanics.
引用
收藏
页码:487 / +
页数:14
相关论文
共 180 条
[1]   Degeneration and aging affect the tensile behavior of human lumbar anulus fibrosus [J].
Acaroglu, ER ;
Iatridis, JC ;
Setton, LA ;
Foster, RJ ;
Mow, VC ;
Weidenbaum, M .
SPINE, 1995, 20 (24) :2690-2701
[2]   THE RELEVANCE OF TORSION TO THE MECHANICAL DERANGEMENT OF THE LUMBAR SPINE [J].
ADAMS, MA ;
HUTTON, WC .
SPINE, 1981, 6 (03) :241-248
[3]   Mechanical initiation of intervertebral disc degeneration [J].
Adams, MA ;
Freeman, BJC ;
Morrison, HP ;
Nelson, IW ;
Dolan, P .
SPINE, 2000, 25 (13) :1625-1636
[4]   'Stress' distributions inside intervertebral discs - The effects of age and degeneration [J].
Adams, MA ;
McNally, DS ;
Dolan, P .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 1996, 78B (06) :965-972
[5]   THE LUMBAR SPINE IN BACKWARD BENDING [J].
ADAMS, MA ;
DOLAN, P ;
HUTTON, WC .
SPINE, 1988, 13 (09) :1019-1026
[6]   The internal mechanical functioning of intervertebral discs and articular cartilage, and its relevance to matrix biology [J].
Adams, Michael A. ;
Dolan, Patricia ;
McNally, Donal S. .
MATRIX BIOLOGY, 2009, 28 (07) :384-389
[7]   EFFECTS OF FLUID INJECTION ON MECHANICAL-PROPERTIES OF INTERVERTEBRAL DISKS [J].
ANDERSSON, GBJ ;
SCHULTZ, AB .
JOURNAL OF BIOMECHANICS, 1979, 12 (06) :453-458
[8]  
Anderst W, 2010, 56 ANN M ORTH RES SO, P146
[9]   The human lumbar intervertebral disc - Evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration [J].
Antoniou, J ;
Steffen, T ;
Nelson, F ;
Winterbottom, N ;
Hollander, AP ;
Poole, RA ;
Aebi, M ;
Alini, M .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (04) :996-1003
[10]   Effects of Torsion on Intervertebral Disc Gene Expression and Biomechanics, Using a Rat Tail Model [J].
Barbir, Ana ;
Godburn, Karolyn E. ;
Michalek, Arthur J. ;
Lai, Alon ;
Monsey, Robert D. ;
Iatridis, James C. .
SPINE, 2011, 36 (08) :607-614