The molecular genetics of astrocytomas: Current understanding and future applications

被引：3

作者：

Walker, DG ^{[1
]}

Lavin, MF ^{[1
]}

机构：

[1] UNIV QUEENSLAND, QUEENSLAND INST MED RES, QUEENSLAND CANC FUND RES UNIT, ROYAL BRISBANE HOSP, BRISBANE, QLD 4029, AUSTRALIA

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 1997年 / 4卷 / 02期

基金：

英国医学研究理事会;

关键词：

astrocytoma; oncogene; tumour suppressor gene; review; genetics;

D O I：

10.1016/S0967-5868(97)90060-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The prognosis for adult patients with astrocytomas remains pear. In recent years there has been a significant amount of research into the molecular mechanisms underlying the development and progression of these tumours. This review describes some of the oncogenes and tumour suppressor genes that are important in the development of astrocytoma, as well as the molecular mechanisms underlying angiogenesis and invasion. Possible clinical applications are described.

引用

页码：114 / 121

页数：8

共 111 条

[91]

SAMOTO K, 1995, CANCER RES, V55, P1189

[92] THE EXPRESSION OF INSULIN-LIKE GROWTH FACTOR-I AND INSULIN-LIKE GROWTH FACTOR-II GENES IN THE HUMAN-FETAL AND ADULT BRAIN AND IN GLIOMA [J].