Rapid Construction of Enantioenriched Benzofurochromanes by SaBOX/Copper(II) Catalyzed Enantioselective [3+2] Annulation of ?-Chromenes with Quinones

被引：13

作者：

Chen, Yang ^{[1
]}

Li, Geng-Xie ^{[2
]}

Peng, Ai-Qing ^{[3
]}

Tang, Yong ^{[3
]}

Wang, Lijia ^{[1
]}

机构：

[1] East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev, Dept Chem, Shanghai 200062, Peoples R China

[2] ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2022年

关键词：

ASYMMETRIC DIELS-ALDER; ALPHA-ARYLATION; IMINE KETALS; ISOFLAVONOIDS; OXINDOLES; LIGANDS; INDOLES;

D O I：

10.1021/acs.orglett.2c01933

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rapid construction of enantioenriched benzofurochromanes was developed by SaBOX/copper(II) catalyzed enantioselective [3 + 2] annulation of gamma-chromenes with quinones. This process takes advantage of the simple starting materials and a highly efficient chiral SaBOX/copper(II) catalyst system, leading to a variety of benzofurochromanes in up to 96% yield with up to 97% ee.

引用

页码：5525 / 5529

页数：5

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