Species choice for comparative genomics: Being greedy works

被引：43

作者：

Pardi, F ^{[1
]}

Goldman, N ^{[1
]}

机构：

[1] EMBL, European Bioinformat Inst, Hinxton, England

来源：

PLOS GENETICS | 2005年 / 1卷 / 06期

关键词：

D O I：

10.1371/journal.pgen.0010071

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Several projects investigating genetic function and evolution through sequencing and comparison of multiple genomes are now underway. These projects consume many resources, and appropriate planning should be devoted to choosing which species to sequence, potentially involving cooperation among different sequencing centres. A widely discussed criterion for species choice is the maximisation of evolutionary divergence. Our mathematical formalization of this problem surprisingly shows that the best long-term cooperative strategy coincides with the seemingly short-term "greedy" strategy of always choosing the next best single species. Other criteria influencing species choice, such as medical relevance or sequencing costs, can also be accommodated in our approach, suggesting our results' broad relevance in scientific policy decisions.

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页码：672 / 675

页数：4

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