Effects of ketamine and pentobarbitone on acetylcholine release from the rat frontal cortex in vivo

被引：35
|
作者：
Kikuchi, T [1 ]
Wang, Y [1 ]
Shinbori, H [1 ]
Sato, K [1 ]
Okumura, F [1 ]
机构：
[1] YOKOHAMA CITY UNIV,SCH MED,DEPT ANESTHESIOL,YOKOHAMA,KANAGAWA 236,JAPAN
来源：
BRITISH JOURNAL OF ANAESTHESIA | 1997年 / 79卷 / 01期
关键词：
nerve; neurotransmitters; anaesthetics i.v; ketamine; hypnotics barbiturate; pentobarbitone; brain; cerebral cortex; rat;
D O I：
10.1093/bja/79.1.128
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
We have studied the effects of ketamine and pentobarbitone on acetylcholine (ACh) release from the rat frontal cortex using microdialysis. Ketamine 25, 50 and 100 mg kg(-1) increased ACh release from the frontal cortex to 286%, 253% and 381% of basal release, respectively. In contrast, pentobarbitone 10, 20 and 40 mg kg(-1) caused 73%, 78% and 96% inhibition of basal levels, respectively. The results suggest that ketamine and pentobarbitone have opposite effects on ACh release from the rat frontal cortex, as seen previously in the rat hippocampus.
引用
收藏
页码：128 / 130
页数：3
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