Cortisol, inflammatory biomarkers and neurotrophins in children and adolescents with attention deficit hyperactivity disorder (ADHD) in Taiwan

被引：63

作者：

Chang, Jane Pei-Chen ^{[1
,2
,3
,4
]}

Mondelli, Valeria ^{[1
]}

Satyanarayanan, Sentil Kumaran ^{[2
,3
]}

Chiang, Yi-Ju ^{[2
,3
,4
]}

Chen, Hui-Ting ^{[2
,3
,4
]}

Su, Kuan-Pin ^{[1
,2
,3
,4
,5
]}

Pariante, Carmine M. ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England

[2] China Med Univ Hosp, Dept Psychiat, 2 Yu Der Rd, Taichung 404, Taiwan

[3] China Med Univ Hosp, MBI Lab, 2 Yu Der Rd, Taichung 404, Taiwan

[4] China Med Univ, Coll Med, 2 Yu Der Rd, Taichung 404, Taiwan

[5] China Med Univ, An Nan Hosp, Tainan, Taiwan

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2020年 / 88卷

基金：

英国医学研究理事会;

关键词：

Attention deficit hyperactivity disorder; Cortisol; HPA axis; Inflammation; Neurotrophins; Youth; NECROSIS-FACTOR-ALPHA; NERVE GROWTH-FACTOR; C-REACTIVE PROTEIN; FACTOR BDNF LEVELS; DEFICIT/HYPERACTIVITY DISORDER; SALIVARY CORTISOL; EXTERNALIZING BEHAVIOR; EXPRESSION PROFILE; BASE-LINE; SERUM;

D O I：

10.1016/j.bbi.2020.05.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Hypothalamus-Pituitary-Adrenal (HPA) axis dysregulation, inflammation and imbalance of neurotrophins have been suggested in attention deficit hyperactivity disorder (ADHD), but the results have not been conclusive. The aim of this study is to investigate the levels of salivary cortisol across 4-time points during the day, and of morning plasma inflammatory biomarkers and neurotrophins, in youth with ADHD and in typically developing youth (TD), with stratification by age, ADHD subtypes and oppositional defiant disorder (ODD) comorbidity in Taiwan. Methods: We conducted a case-control study measuring saliva cortisol levels at 4 different time points during the day (at awakening, noon, 1800 h and bedtime) and morning plasma levels of inflammatory and neurotrophins biomarkers in youth with ADHD (n = 98, age 6-18 years old with mean age 9.32 +/- 3.05 years) and TD (n = 21, age 6-18 years old with mean age 9.19 +/- 2.96 years) in Taiwan. Results: Our study showed that youth with ADHD had lower levels of bedtime salivary cortisol (effects size (ES) = -0.04, p =.023), with children with the combined form of the disorder (with inattention, hyperactivity and impulsivity all present) having the lowest awakening salivary cortisol levels. ADHD youth also had higher levels of plasma high-sensitivity C-reactive protein (hs-CRP) and interleukin (IL)-6 (ES = 0.85-1.20, p <.0001), and lower plasma tumor necrosis factor-alpha (ES = -0.69, p =.009) and brain-derived neurotrophic factors (BDNF) (ES = -1.13, p <.0001). Both ADHD groups regardless of ODD comorbidity had higher levels of IL-6 (p <.0001) and lower levels BDNF (p <.0001). Conclusion: The lower bedtime salivary cortisol levels and higher levels of inflammatory biomarkers in youth with ADHD further support the role of abnormal HPA axis and inflammation in ADHD. Moreover, the lower levels of BDNF in ADHD also indicate that BDNF may be a potential biomarker in this disorder that is part of a broader biological dysfunction.

引用

页码：105 / 113

页数：9

共 79 条

[1] Cortisol and externalizing behavior in children and adolescents: Mixed meta-analytic evidence for the inverse relation of basal cortisol and cortisol reactivity with externalizing behavior [J].