Prenatal smoke (Nicotine) exposure and offspring's metabolic disease susceptibility in adulthood

被引：10

作者：

He, Bo ^{[1
,5
,6
]}

Zhang, Qi ^{[1
,3
]}

Guo, Yu ^{[1
,3
]}

Ao, Ying ^{[1
,3
]}

Tie, Kai ^{[2
,3
]}

Xiao, Hao ^{[2
,3
]}

Chen, Liaobin ^{[2
,3
]}

Xu, Dan ^{[3
,4
,7
]}

Wang, Hui ^{[1
,3
,4
]}

机构：

[1] Basic Med Sch Wuhan Univ, Dept Pharmacol, Wuhan 430071, Peoples R China

[2] Wuhan Univ, Dept Orthoped Surg, Zhongnan Hosp, Wuhan 430071, Peoples R China

[3] Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R China

[4] Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Pharm, Wuhan 430071, Peoples R China

[5] Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China

[6] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China

[7] Zhongnan Hosp Wuhan Univ, Wuhan Univ, Sch Pharmaceut Sci, Dept Pharm,Hubei Provincial Key Lab Dev Originated, Wuhan 430071, Peoples R China

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2022年 / 168卷

基金：

中国国家自然科学基金;

关键词：

Smoke; Nicotine; Intrauterine programming; Metabolic diseases; Glucocorticoids; INTRAUTERINE GROWTH-RETARDATION; LONG-TERM CONSEQUENCES; HIGH-FAT DIET; INFANT-DEATH-SYNDROME; BETA-CELL APOPTOSIS; LOW-BIRTH-WEIGHT; MATERNAL-SMOKING; CIGARETTE-SMOKING; BLOOD-PRESSURE; ADRENAL AXIS;

D O I：

10.1016/j.fct.2022.113384

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Exposure to smoking (nicotine) during pregnancy not only directly affects fetal development, but also increases susceptibility to metabolic diseases in adulthood, but the mechanism of action remains unclear. Here, we review epidemiological and laboratory studies linking these relationships. In addition to the direct effect of nicotine on the fetus, intrauterine neuroendocrine-metabolic programming mediated by maternal glucocorticoid over-exposure also plays an important role, involving glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis, hypothalamic-pituitary-adrenal (HPA) axis, renin-angiotensin system (RAS) and other endocrine systems. Epi-genetics is involved in intrauterine neuroendocrine-metabolic programming, metabolic disease susceptibility and multigenerational inheritance. There are "two programming" and "two strikes" mechanisms for the occurrence of fetal-originated metabolic diseases in adulthood. These innovative research summaries and academic viewpoints provide experimental and theoretical basis for systematically elucidating the occurrence and development of fetal-originated metabolic diseases.

引用

页数：12

共 147 条

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