SYNTHESIS OF NEW FUNCTIONALIZED CHIRAL IONIC LIQUID AND ITS ORGANOCATALYTIC ASYMMETRIC MICHAEL ADDITION

被引：13
|
作者：
Li, Jian [2 ]
Liu, Li [1 ]
机构：
[1] Chang Zhou Univ, Analyt Ctr, Changzhou 213164, Peoples R China
[2] Chang Zhou Univ, Sch Pharmaceut Engn & Life Sci, Changzhou, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2013年 / 43卷 / 04期
关键词：
Asymmetric Michael addition; chiral ionic liquid; recyclable; SUPPORTED ORGANOCATALYST; KETONES; CATALYSTS; EFFICIENT; PROLINE; CYCLOHEXANONE;
D O I：
10.1080/00397911.2011.602498
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel recyclable functionalized chiral ionic liquid has been developed to promote asymmetric Michael additions of cyclohexanone to both aryl and alkyl nitroolefins in the presence of 20 mol% of organocatalyst 4 in MeOH. The process affords synthetically valuable chiral products in good yields (up to 93%) and high enantioselectivities (up to 92%). The chiral ionic liquid could be easily reused six times without remarkable decrease in yields and enantioselectivities.
引用
收藏
页码：476 / 485
页数：10
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